Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma.
Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma.
复制标题
DOI：
10.3390/cancers13112810
复制
发表时间：
2021-06-04
期刊：
影响因子：
5.2
通讯作者：
Limatola C
中科院分区：
文献类型：
--
作者：
D'Alessandro G;Lauro C;Quaglio D;Ghirga F;Botta B;Trettel F;Limatola C
在过去的几年里，许多证据表明肠道微生物和大脑之间存在意想不到的双向交流。肠道微生物群衍生的分子可以在生理和病理条件下影响神经系统，甚至调节神经递质水平。在这里，我们总结了神经递质对成人脑和脑胶质瘤中神经元前体细胞增殖和分化的影响。此外，我们讨论了肠道微生物群对神经递质的调节可能影响脑肿瘤，特别是神经胶质瘤的发展和进展的假设。需要进一步研究参与双向肠-脑通讯的机制，以确定新的分子和细胞靶点参与胶质瘤中发生的脑内稳态失调。胶质母细胞瘤（GBM）是成人脑中最具侵袭性的胶质瘤。在负责GBM细胞增殖和侵袭的众多因素中，神经递质如多巴胺、5-羟色胺和谷氨酸可以发挥关键作用。在无菌（GF）条件下饲养的小鼠中进行的研究证明了肠-脑轴在许多生理和病理条件下的相关性。肠-脑通信通过迷走神经/神经和血液/淋巴途径成为可能，并为功能的相互调节铺平道路。肠道微生物群产生和消耗各种分子，包括神经递质（多巴胺，去甲肾上腺素，5-羟色胺，γ-氨基丁酸[GABA]和谷氨酸），通过血流到达其细胞靶点。动物中越来越多的证据表明，微生物群对这些神经递质的调节影响宿主神经生理学和行为，并影响神经祖细胞和神经胶质细胞，沿着对肿瘤细胞生长的影响。在这篇综述中，我们提出了一个新的观点，将肠道微生物群的神经递质调节与胶质瘤进展联系起来。
In the last few years, a lot of evidence demonstrated an unexpected bidirectional communication among the gut microbes and the brain. Gut microbiota derived molecules may affect the nervous system in physiological and pathological conditions, even modulating neurotransmitter levels. Here, we summarize the effects of neurotransmitters on the proliferation and differentiation of neuronal precursor cells in the adult brain, and in brain gliomas. Further, we discuss the hypothesis that modulation of neurotransmitters by gut microbiota might impact the development and progress of brain tumor, specifically glioma. Further investigation on the mechanisms involved in the bidirectional gut-brain communication is required to identify new molecular and cellular targets involved in the dysregulation of brain homeostasis occurring in glioma. Glioblastoma (GBM) is the most aggressive form of glioma tumor in adult brain. Among the numerous factors responsible for GBM cell proliferation and invasion, neurotransmitters such as dopamine, serotonin and glutamate can play key roles. Studies performed in mice housed in germ-free (GF) conditions demonstrated the relevance of the gut-brain axis in a number of physiological and pathological conditions. The gut–brain communication is made possible by vagal/nervous and blood/lymphatic routes and pave the way for reciprocal modulation of functions. The gut microbiota produces and consumes a wide range of molecules, including neurotransmitters (dopamine, norepinephrine, serotonin, gamma-aminobutyric acid [GABA], and glutamate) that reach their cellular targets through the bloodstream. Growing evidence in animals suggests that modulation of these neurotransmitters by the microbiota impacts host neurophysiology and behavior, and affects neural cell progenitors and glial cells, along with having effects on tumor cell growth. In this review we propose a new perspective connecting neurotransmitter modulation by gut microbiota to glioma progression.
登录
查看更多内容
影响因子：
4.3
作者：
Bonaz B;Bazin T;Pellissier S
通讯作者：
Pellissier S
影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
影响因子：
3.6
作者：
Catavero C;Bao H;Song J
通讯作者：
Song J
影响因子：
8.1
作者：
Cani PD;Knauf C
通讯作者：
Knauf C
影响因子：
4
作者：
Barrett, E.;Ross, R. P.;Stanton, C.
通讯作者：
Stanton, C.