A new era in the treatment of systemic juvenile idiopathic arthritis.
A new era in the treatment of systemic juvenile idiopathic arthritis.
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系统性幼年特发性关节炎治疗的新时代。
DOI:
10.1056/nejme1212640
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
Mellins,ElizabethD
中科院分区:
文献类型:
--
作者:
Sandborg,Christy;Mellins,ElizabethD
Advances in understanding the biology of inflammation have spurred drug development and revolutionized the care of both adults and children with rheumatic diseases. Among the most dramatic examples of this progress are the clinical trials, reported by Ruperto et al.1and De Benedetti et al.2in this issue of theJournal,of two different biologic agents — the interleukin-1 inhibitor, canakinumab, and the interleukin-6 inhibitor, tocilizumab — for the treatment of systemic juvenile idiopathic arthritis (JIA). These studies represent the culmination of work begun in small, but encouraging studies involving patients with systemic JIA who received treatment with interleukin-1 or . . .
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DOI:
10.1016/s0021-9258(18)89161-x
发表时间:
1985-04
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
H. Egge;M. Kordowicz;J. Peter-Katalinic;P. Hanfland
通讯作者:
H. Egge;M. Kordowicz;J. Peter-Katalinic;P. Hanfland
影响因子:
2.7
作者:
M. Nishigaki;K. Yamashita;I. Matsuda;S. Arashima;A. Kobata
通讯作者:
A. Kobata
DOI:
--
发表时间:
1981
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Goldstein,IJ;Blake,DA;Ebisu,S;Williams,TJ;Murphy,LA
通讯作者:
Murphy,LA
影响因子:
3.9
作者:
CLARK, GF;KRIVAN, HC;SMITH, DF
通讯作者:
SMITH, DF
影响因子:
4.8
作者:
L. A. Murphy;I. Goldstein
通讯作者:
I. Goldstein