A new era in the treatment of systemic juvenile idiopathic arthritis.

A new era in the treatment of systemic juvenile idiopathic arthritis.
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系统性幼年特发性关节炎治疗的新时代。

DOI:
10.1056/nejme1212640
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发表时间:
2012
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Mellins,ElizabethD
Mellins,ElizabethD
中科院分区:
--
文献类型:
--
作者:
Sandborg,Christy;Mellins,ElizabethD

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了解炎症生物学的进步刺激了药物开发,并彻底改变了成人和儿童风湿性疾病的护理。这一进展中最引人注目的例子是由Ruperto等人和De Benedetti等人在本期《杂志》上报道的两种不同生物制剂的临床试验——白细胞介素-1抑制剂canakinumab和白细胞介素-6抑制剂tocilizumab——用于治疗系统性幼年特发性关节炎(JIA)。这些研究代表了小规模但令人鼓舞的系统性JIA患者接受白细胞介素-1或…治疗的研究工作的高潮。
Advances in understanding the biology of inflammation have spurred drug development and revolutionized the care of both adults and children with rheumatic diseases. Among the most dramatic examples of this progress are the clinical trials, reported by Ruperto et al.1and De Benedetti et al.2in this issue of theJournal,of two different biologic agents — the interleukin-1 inhibitor, canakinumab, and the interleukin-6 inhibitor, tocilizumab — for the treatment of systemic juvenile idiopathic arthritis (JIA). These studies represent the culmination of work begun in small, but encouraging studies involving patients with systemic JIA who received treatment with interleukin-1 or . . .
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影响因子: --
作者:
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