A Perspective on Cortical Layering and Layer-Spanning Neuronal Elements.

A Perspective on Cortical Layering and Layer-Spanning Neuronal Elements.
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DOI:
10.3389/fnana.2018.00056
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发表时间:
2018
影响因子:
2.9
通讯作者:
Muckli L
Muckli L
中科院分区:
医学3区
文献类型:
--
作者:
Larkum ME;Petro LS;Sachdev RNS;Muckli L

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这篇综述文章讨论了大脑皮层各层的功能。我们发展了这样一种观点,即皮质分层需要从其功能解剖学的角度来理解,即,不同细胞区室上突触输入的终止及其对皮层活动的影响。皮层是一个分层结构,其中前馈和反馈通路具有层特异性终止模式。我们认为,到达不同皮质层的突触输入的影响,只能理解其复杂的相互作用与细胞生物物理学和随后的计算,发生在细胞水平。我们使用高分辨率的功能磁共振成像,它可以解决跨层的活动,作为实施这种方法的案例研究,通过描述如何认知事件所产生的层状分布的输入可以被解释,考虑到跨不同层的神经元的属性。这种观点是基于最近的进展,在测量亚细胞活动在不同的前馈和反馈轴突和树突,因为它们跨越层。
This review article addresses the function of the layers of the cerebral cortex. We develop the perspective that cortical layering needs to be understood in terms of its functional anatomy, i.e., the terminations of synaptic inputs on distinct cellular compartments and their effect on cortical activity. The cortex is a hierarchical structure in which feed forward and feedback pathways have a layer-specific termination pattern. We take the view that the influence of synaptic inputs arriving at different cortical layers can only be understood in terms of their complex interaction with cellular biophysics and the subsequent computation that occurs at the cellular level. We use high-resolution fMRI, which can resolve activity across layers, as a case study for implementing this approach by describing how cognitive events arising from the laminar distribution of inputs can be interpreted by taking into account the properties of neurons that span different layers. This perspective is based on recent advances in measuring subcellular activity in distinct feed-forward and feedback axons and in dendrites as they span across layers.
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