Antigens on HTLV-infected cells recognized by leukemia and AIDS sera are related to HTLV viral glycoprotein.
Antigens on HTLV-infected cells recognized by leukemia and AIDS sera are related to HTLV viral glycoprotein.
复制标题
白血病和艾滋病血清识别的HTLV感染细胞上的抗原与HTLV病毒糖蛋白有关。
作者：
J. Schüpbach;M. Sarngadharan;R. Gallo
分子大小为61，000至68，000道尔顿的交叉反应性抗原存在于被人T细胞白血病-淋巴瘤病毒（HTLV）感染的人细胞表面。它们被成人T细胞白血病和淋巴瘤患者、HTLV健康携带者和获得性免疫缺陷综合征（AIDS）患者的抗体识别。后一个发现是提示HTLV与艾滋病相关的主要原因之一。然而，这些抗原是否是细胞或病毒来源还不清楚。这些抗原现已被证明与细胞中病毒蛋白的存在有关，并且已发现分子大小为46，000道尔顿的交叉反应性糖蛋白是从几种HTLV生产细胞系纯化的病毒的一致结构部分。因此，研究结果表明这些抗原的病毒（HTLV）来源。
Cross-reactive antigens of molecular size of 61,000 to 68,000 daltons are found on the surface of human cells infected by human T-cell leukemia-lymphoma virus (HTLV). They are recognized by antibodies from patients with adult T-cell leukemias and lymphomas, from healthy carriers of HTLV, and from patients with the acquired immunodeficiency syndrome (AIDS). The latter finding has been one of the major reasons for suggesting an association of HTLV with AIDS. However, whether these antigens are of cellular or viral origin has not been clear. These antigens have now been shown to be associated with the presence of viral proteins in the cells, and a cross-reactive glycoprotein of molecular size of 46,000 daltons has been found to be a consistent structural part of viruses purified from several HTLV-producer cell lines. The findings thus suggest a viral (HTLV) origin of these antigens.
血友病患者中的人类 T 细胞白血病病毒膜抗原 (HTLV-MA) 抗体。
DOI：
10.1126/science.6603659
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Essex,M;McLane,MF;Lee,TH;Tachibana,N;Mullins,JI;Kreiss,J;Kasper,CK;Poon,MC;Landay,A;Stein,SF;Francis,DP;Cabradilla,C;Lawrence,DN;Evatt,BL
通讯作者：
Evatt,BL