Contribution of the -160C/A polymorphism in the E-cadherin promoter to cancer risk: a meta-analysis of 47 case-control studies.
Contribution of the -160C/A polymorphism in the E-cadherin promoter to cancer risk: a meta-analysis of 47 case-control studies.
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E-钙粘蛋白启动子中 -160C/A 多态性对癌症风险的贡献：47 项病例对照研究的荟萃分析
DOI：
10.1371/journal.pone.0040219
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kang J
中科院分区：
文献类型：
--
作者：
Wang L;Wang G;Lu C;Feng B;Kang J
研究背景E-cadherin基因的-160C/A多态性（rs 16260）是多种肿瘤的易感等位基因。由于这种多态性对癌症风险的重要性已经被认识到，越来越多的研究调查了不同类型癌症和种族人群中的-160C/A。然而，各种癌症的风险水平仍然存在不确定性。方法为了解决截至2012年3月这些研究提出的有争议的问题，并为检测-160C/A的意义提供更多的统计学把握度，我们对16种癌症的47项病例对照研究（18，194例病例和20，207例对照）进行了荟萃分析。采用元回归模型和亚组分析来确定异质性的来源。评价发表偏倚，并进行敏感性分析和累积证据评估。结果采用固定效应和随机效应模型，-160AA纯合子比-160CA杂合子更易患尿路上皮癌。此外，-160A等位基因是前列腺癌和结直肠癌的种族依赖性风险因素。亚洲人和欧洲人中携带-160A等位基因的人更容易患前列腺癌，而他们的北美人似乎对前列腺癌很宽容。-160AA纯合子对欧洲人患结直肠癌起保护作用。这些观察结果的稳定性通过单向敏感性分析得到证实。然而，使用威尼斯指南，所有癌症类型的累积证据被认为是“弱”的。结论E-cadherin基因-160A等位基因与前列腺癌和尿路上皮癌的发生相关，对结直肠癌的发生具有保护作用。
Background The -160C/A polymorphism (rs16260) of E-cadherin, a tumor repressor gene, has been shown to be a tumor susceptibility allele for various types of cancers. Because the significance of this polymorphism to cancer risk has been recognized, there are increasing studies investigating -160C/A in different types of cancers and ethnic populations. However, there is still uncertainty about the level of risk for a variety of cancers. Methods To resolve the controversial question raised by these studies as of March 2012 and provide more statistical power for detecting the significance of -160C/A, we performed a meta-analysis of 47 case-control studies in 16 types of cancers (18,194 cases and 20,207 controls). A meta-regression model and subgroup analysis were employed to identify the source of heterogeneity. Publication bias was evaluated, and sensitivity analysis and cumulative evidence assessment were also performed. Results Using fixed- and random-effects models, the -160AA homozygote was more susceptible to urothelial cancer compared with the -160CA heterozygote. Additionally, the -160A allele is an ethnicity-dependent risk factor for prostate and colorectal cancers. Carriers of the -160A allele in Asians and Europeans were more susceptible to prostate cancer, whereas their North American counterparts seemed tolerant. The -160AA homozygote plays a protective role for Europeans who develop colorectal cancer. The stability of these observations was confirmed by a one-way sensitivity analysis. However, the cumulative evidence for all cancer types was considered ‘weak’ using the Venice guidelines. Conclusions A meta-analysis indicated that the -160A allele of E-cadherin provides a higher risk for the development of prostate and urothelial cancers and a protective role for colorectal cancer in an ethnicity-dependent manner.
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影响因子：
8.4
作者：
Kiemeney, Lambertus A.;van Houwelingen, Kjeld P.;Verhaegh, Gerald W.
通讯作者：
Verhaegh, Gerald W.
影响因子：
2
作者：
Harbord, Roger M.;Egger, Matthias;Sterne, Jonathan A. C.
通讯作者：
Sterne, Jonathan A. C.
影响因子：
6.4
作者：
Jonsson, BA;Adami, HO;Grönberg, H
通讯作者：
Grönberg, H
DOI：
10.3324/haematol.2010.033126
发表时间：
2011-07-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Jacobs, Gunnar;Hellmig, Stephan;Rosenstiel, Philip
通讯作者：
Rosenstiel, Philip
影响因子：
8.4
作者：
Jenab, Mazda;McKay, James D.;Gonzalez, Carlos
通讯作者：
Gonzalez, Carlos