The differential expression of IL-4 and IL-13 and its impact on type-2 immunity.
The differential expression of IL-4 and IL-13 and its impact on type-2 immunity.
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DOI：
10.1016/j.cyto.2015.05.008
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发表时间：
2015-09
期刊：
影响因子：
3.8
通讯作者：
Reinhardt, R. Lee
中科院分区：
文献类型：
--
作者：
Bao, Katherine;Reinhardt, R. Lee
过敏性疾病是一个重大的全球健康负担，世界城市地区的发病率继续上升。因此，更好地了解疾病病理的基本免疫机制可能是开发治疗干预措施的关键，以预防疾病的发病，并改善那些已经患有与2型炎症有关的疾病的人的疾病发病率。2型免疫的两个核心因素是白介素4和白介素13。这两种细胞因子几乎与所有与2型炎症相关的主要疾病特征有关。因此，IL-4和IL-13及其调控通路是抑制疾病的理想靶点。然而，尽管有许多共同的调节途径和受体，这些细胞因子在2型免疫反应中发挥着非常不同的功能。本文综述了有关IL-4和IL-13在CD4+T细胞和天然免疫细胞中的功能和表达的文献。它强调了最近在体内发现的关于IL-4和IL-13在各种免疫细胞中的差异表达和非规范调节，它们在2型变态反应免疫中可能扮演着被低估的重要角色。
Allergic disease represents a significant global health burden, and disease incidence continues to rise in urban areas of the world. As such, a better understanding of the basic immune mechanisms underlying disease pathology are likely the key to developing therapeutic interventions to both prevent disease onset as well as to ameliorate disease morbidity in those individuals already suffering from a disorder linked to type-2 inflammation. Two factors central to type-2 immunity are interleukin(IL)-4 and IL-13. These two cytokines have been linked to virtually all of the major disease hallmarks associated with type-2 inflammation. Therefore, IL-4 and IL-13 and their regulatory pathways represent ideal targets to suppress disease. However, despite sharing many common regulatory pathways and receptors, these cytokines perform very distinct functions during a type-2 immune response. This review summarizes the literature surrounding the function and expression of IL-4 and IL-13 in CD4+ T cells and innate immune cells. It highlights recent in vivo findings regarding the differential expression and non-canonical regulation of IL-4 and IL-13 in various immune cells, which likely play an underappreciated and important role in type-2 allergic immunity.
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DOI：
10.1073/pnas.92.16.7565
发表时间：
1995-08-01
影响因子：
11.1
作者：
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影响因子：
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发表时间：
2006-06-12
期刊：
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