Membrane-Mediated Interactions Between Protein Inclusions.

Membrane-Mediated Interactions Between Protein Inclusions.
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DOI:
10.3389/fmolb.2021.811711
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发表时间:
2021
影响因子:
5
通讯作者:
Hu J
Hu J
中科院分区:
生物学3区
文献类型:
--
作者:
Gao J;Hou R;Li L;Hu J

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整体或外周膜蛋白,或蛋白质寡聚体通常在细胞膜上彼此靠近,并以集体的方式执行生物学任务。除了静电和货车范德华相互作用,这些蛋白质还经历膜介导的相互作用,这可能是它们的功能所必需的。膜介导的相互作用起源于蛋白质内含物的存在对脂质膜的扰动,并且一直是膜生物物理学中深入研究的主题。在这里,我们回顾这种相互作用的膜蛋白和纳米粒子结合到脂质膜的理论和数值研究。
Integral or peripheral membrane proteins, or protein oligomers often get close to each other on cell membranes and carry out biological tasks in a collective manner. In addition to electrostatic and van der Waals interactions, those proteins also experience membrane-mediated interactions, which may be necessary for their functionality. The membrane-mediated interactions originate from perturbation of lipid membranes by the presence of protein inclusions, and have been the subject of intensive research in membrane biophysics. Here we review both theoretical and numerical studies of such interactions for membrane proteins and for nanoparticles bound to lipid membranes.
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