Age alters gait compensations following meniscal injury in male rats.
Age alters gait compensations following meniscal injury in male rats.
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DOI：
10.1002/jor.25306
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发表时间：
2022-12
影响因子：
2.8
通讯作者：
Allen, Kyle D.
中科院分区：
文献类型：
--
作者：
Chan, Kiara M.;Yeater, Taylor D.;Allen, Kyle D.
随着年龄的增长，骨关节炎（OA）和OA相关疼痛和残疾的易感性增加。与OA患者一样，啮齿动物OA模型中的步态模式在负载期间发生变化以保护受伤肢体。然而，与OA患者不同，年龄如何影响啮齿动物OA模型中的步态变化尚不清楚。在这项工作中，步态补偿后，踝关节损伤的3个月，6个月和9个月大的大鼠进行了评估，以检查OA相关的关节功能障碍的年龄效应。在3、6和9个月时，大鼠接受内侧副韧带横断加内侧半月板横断（MCLT+MMT）手术（n=8/年龄组）或皮肤切口（n=8/年龄组）。术后，大鼠在2、4、6和8周进行步态测试。死后，对关节进行组织学处理以评估软骨损伤。MCLT+MMT大鼠在受伤后立即和整个OA进展过程中，在受伤肢体的垂直负荷减少的情况下行走。与假手术肢体相比，6个月和9个月的MCLT+MMT动物减少了其受伤肢体的负荷，而3个月的MCLT+MMT动物没有。与对侧肢体相比，MCLT+MMT大鼠还增加了受伤肢体的站立时间。此外，对于MCLT+MMT动物，与3个月动物相比，6个月和9个月动物的软骨损伤显著更严重。这些数据表明，受伤时的年龄影响动物如何加载OA影响的关节，年龄较大的动物发展步态补偿，更显着地减少行走过程中受伤肢体的重量。
With age, susceptibility to osteoarthritis (OA) and OA-related pain and disability increases. Like in OA patients, gait patterns in rodent OA models shift to protect the injured limb during loading. However, unlike in OA patients, it is unknown how age affects gait changes in rodent OA models. In this work, gait compensations following meniscal injury in 3-, 6-, and 9-month-old rats were evaluated to examine age-effects of OA-related joint dysfunction. Rats at 3, 6, and 9 months received medial collateral ligament transection plus medial meniscus transection (MCLT+MMT) surgery (n=8/age group) or a skin-incision (n=8/age group). Post-surgery, rats underwent gait testing at 2, 4, 6, and 8 weeks. Post-mortem, joints were processed for histology to assess cartilage damage. MCLT+MMT rats walked with reduced vertical loading in their injured limbs immediately after injury and throughout OA progression. Compared to sham-operated limbs, 6- and 9-month MCLT+MMT animals reduced loading in their injured limbs while 3-month MCLT+MMT animals did not. MCLT+MMT rats also increased stance time on the injured limb compared to the contralateral limb. Additionally, for the MCLT+MMT animals, 6- and 9-month animals had significantly worse cartilage damage compared to 3-month animals. These data indicated age at injury onset affects how animals load the OA-affected joint, with older animals developing gait compensations that more markedly reduce weight on the injured limb during walking.
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影响因子：
7
作者：
Lakes, E. H.;Allen, K. D.
通讯作者：
Allen, K. D.
影响因子：
7
作者：
Bannuru, R. R.;Osani, M. C.;McAlindon, T. E.
通讯作者：
McAlindon, T. E.
影响因子：
2.3
作者：
Bedson, John;Croft, Peter R.
通讯作者：
Croft, Peter R.
影响因子：
2.8
作者：
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通讯作者：
Nichols, T. Richard
影响因子：
2.4
作者：
Duffell, Lynsey D.;Jordan, Stevan J.;McGregor, Alison H.
通讯作者：
McGregor, Alison H.