The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.
The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.
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DOI：
10.1016/j.devcel.2008.07.017
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发表时间：
2008-10
影响因子：
11.8
通讯作者：
Hadjantonakis, Anna-Katerina
中科院分区：
文献类型：
--
作者：
Kwon, Gloria S.;Viotti, Manuel;Hadjantonakis, Anna-Katerina
在胚胎内胚层形态发生的基础上的细胞运动是复杂的，还没有很好的理解。利用活体成像技术结合遗传标记技术，研究了小鼠原肠胚内胚层形成过程中内脏内胚层的细胞行为和命运。与流行的观点相反，我们的数据显示内脏内胚层没有大规模移位到胚外区域伴随着外胚层衍生的定形内胚层的出现。相反，我们观察到内脏内胚层上皮的分散和内脏内胚层和上胚层起源的细胞之间的广泛混合。内脏内胚层细胞仍然与上胚层相关联，并被纳入早期肠管。我们的研究结果表明，哺乳动物胚胎中胚外组织和胚胎组织的分离并不像人们所认为的那样严格，而且以前定义为专门的胚外细胞的谱系为胚胎提供了细胞。
The cell movements underlying the morphogenesis of the embryonic endoderm, the tissue that will give rise to the respiratory and digestive tracts, are complex and not well understood. Using live imaging combined with genetic labeling, we investigated the cell behaviors and fate of the visceral endoderm during endoderm formation in the mouse gastrula. Contrary to the prevailing view, our data reveal no mass displacement of visceral endoderm to extraembryonic regions concomitant with the emergence of epiblast-derived definitive endoderm. Instead, we observed dispersal of the visceral endoderm epithelium and extensive mixing between cells of visceral endoderm and epiblast origin. Visceral endoderm cells remained associated with the epiblast and were incorporated into the early gut tube. Our findings suggest that the segregation of extraembryonic and embryonic tissues within the mammalian embryo are not as strict as believed, and that a lineage previously defined as exclusively extraembryonic contributes cells to the embryo.
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影响因子：
2.6
作者：
Hadjantonakis, AK;Gertsenstein, M;Nagy, A
通讯作者：
Nagy, A
影响因子：
2.6
作者：
Hayashi, Shigemi;Lewis, Paula;McMahon, Andrew P.
通讯作者：
McMahon, Andrew P.
DOI：
10.1073/pnas.87.17.6589
发表时间：
1990-09-01
影响因子：
11.1
作者：
COSTA, RH;VANDYKE, TA;DARNELL, JE
通讯作者：
DARNELL, JE
影响因子：
5.3
作者：
KRUMLAUF, R;HAMMER, RE;BRINSTER, RL
通讯作者：
BRINSTER, RL
DOI：
10.1242/dev.014357
发表时间：
2008-02
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Arnold SJ;Hofmann UK;Bikoff EK;Robertson EJ
通讯作者：
Robertson EJ