Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications.
Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications.
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DOI：
10.2174/138161210790963788
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发表时间：
2010
影响因子：
3.1
通讯作者：
Brown KC
中科院分区：
文献类型：
--
作者：
Brown KC
癌症已成为美国人的头号死因，每天约有1,600人死亡。早期检测的新方法和有效治疗的发展是医学领域的一个突出优先事项。因此，肿瘤特异性配体的分离是一个不断发展的研究领域。肿瘤特异性结合剂可用于探测肿瘤细胞表面表型，并通过将适当的细胞靶向配体与抗癌药物缀合来相应地定制治疗。这改进了肿瘤的分子诊断，并创建了可以靶向肿瘤同时保留健康组织的指导药物。此外，这些靶向剂可用作体内成像剂，其允许肿瘤和微转移的早期检测。噬菌体展示技术是一种有效的分离多肽的技术，它能以高亲和力和特异性结合特定的靶点。动物中完整癌细胞或肿瘤的生物淘选可用于分离与癌症特异性细胞表面生物标志物结合的肽。在过去的10年中，噬菌体展示肽库的无偏生物淘选已经产生了一套癌症靶向肽配体。本文综述了近年来通过无偏生物淘选方法分离肿瘤靶向肽的研究进展，并重点介绍了分离肽在临床应用中的应用。
Cancer has become the number one cause of death amongst Americans, killing approximately 1,600 people per day. Novel methods for early detection and the development of effective treatments are an eminent priority in medicine. For this reason, isolation of tumor-specific ligands is a growing area of research. Tumor-specific binding agents can be used to probe the tumor cell surface phenotype and customize treatment accordingly by conjugating the appropriate cell-targeting ligand to an anticancer drug. This refines the molecular diagnosis of the tumor and creates guided drugs that can target the tumor while sparing healthy tissues. Additionally, these targeting agents can be used as in vivo imaging agents that allow for earlier detection of tumors and micrometastasis. Phage display is a powerful technique for the isolation of peptides that bind to a particular target with high affinity and specificity. The biopanning of intact cancer cells or tumors in animals can be used to isolate peptides that bind to cancer-specific cell surface biomarkers. Over the past 10 years, unbiased biopanning of phage-displayed peptide libraries has generated a suite of cancer targeting peptidic ligands. This review discusses the recent advances in the isolation of cancer-targeting peptides by unbiased biopanning methods and highlights the use of the isolated peptides in clinical applications.
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影响因子：
--
作者：
De, J;Chang, YC;Brown, KC
通讯作者：
Brown, KC
影响因子：
3
作者：
Devemy, Emmanuelle;Blaschuk, Orest W.
通讯作者：
Blaschuk, Orest W.
DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
通讯作者：
Ruoslahti, E
影响因子：
4.7
作者：
Derfus, Austin M.;Chen, Alice A.;Bhatia, Sangeeta N.
通讯作者：
Bhatia, Sangeeta N.
影响因子：
20.3
作者：
Bieker, Ralf;Kessler, Torsten;Berdel, Wolfgang E.
通讯作者：
Berdel, Wolfgang E.