Sodium Butyrate Ameliorates Gut Microbiota Dysbiosis in Lupus-Like Mice.
Sodium Butyrate Ameliorates Gut Microbiota Dysbiosis in Lupus-Like Mice.
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丁酸钠改善狼疮样小鼠肠道微生物群失调
DOI：
10.3389/fnut.2020.604283
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发表时间：
2020
影响因子：
5
通讯作者：
Nie Y
中科院分区：
文献类型：
--
作者：
He H;Xu H;Xu J;Zhao H;Lin Q;Zhou Y;Nie Y
肠道菌群对系统性红斑狼疮（SLE）的发生和发展有很大影响，一些研究已经证明了微生物来源的丁酸盐改善SLE的有效性。然而，丁酸盐在SLE中对肠道微生物群的作用尚不清楚。使用MRL/lpr狼疮易感小鼠，我们通过16 S rRNA测序检查了丁酸盐治疗后的肠道微生物群谱。狼疮样疾病小鼠肠道微生物组的变化主要表现为微生物多样性减少，拟杆菌属丰度增加，厚壁菌门减少。用丁酸盐处理狼疮易感小鼠导致厚壁菌门的丰度增加（P = 0.003），梭菌（P = 0.005），梭菌（P = 0.005），毛螺菌科（P = 0.009），瘤胃球菌科（P = 0.021），消化链球菌科（P = 0.021），瘤胃梭菌（P = 0.016），颤杆菌属（P = 0.048），Romboutsia（P = 0.025）、毛梭菌属（P = 0.012）、粪球菌属（P = 0.015）、瘤胃球菌属（P = 0.011）、纤细梭菌属（P < 0.05）、多瑞亚菌属（P < 0.05）。（P = 0.019），拟杆菌（P = 0.004）、拟杆菌（P = 0.004）和拟杆菌目（P = 0.004）的比例降低。此外，补充丁酸盐可以改善肾损伤。总的来说，这项研究表明，在丁酸盐治疗后，MRL/lpr狼疮易感小鼠的肠道微生物群发生了变化。丁酸补充改善肠道微生物群失调。这些发现支持丁酸盐和丁酸盐产生菌作为SLE的潜在治疗方法。
Gut microbiota has a strong influence on the onset and development of systemic lupus erythematosus (SLE), and several studies have demonstrated the effectiveness of microbiota-derived butyrate to ameliorate SLE. However, the roles of butyrate on gut microbiota in SLE are not understood. Using MRL/lpr lupus-prone mice, we examined gut microbiota profiles after butyrate treatment by 16S rRNA sequencing. Alterations in intestinal microbiome in mice with lupus-like disease were mainly characterized by a reduction in microbial diversity, with an increased abundance of Bacteroidetes and a decrease of Firmicutes. Treatment of lupus-prone mice with butyrate resulted in increased abundance of Firmicutes (P = 0.003), Clostridia (P = 0.005), Clostridiales (P = 0.005), Lachnospiraceae (P = 0.009), Ruminococcaceae (P = 0.021), Peptostreptococcaceae (P = 0.021), Ruminiclostridium (P = 0.016), Oscillibacter (P = 0.048), Romboutsia (P = 0.025), Lachnoclostridium (P = 0.012), Coprococcus (P = 0.015), Ruminococcus (P = 0.011), Clostridium leptum (P < 0.05), and Dorea_spp. (P = 0.019), and a reduced proportion of Bacteroidetes (P = 0.004), Bacteroidia (P = 0.004), and Bacteroidales (P = 0.004). Further, butyrate supplementation could ameliorate kidney damage. Overall, this study suggests that gut microbiota alterations occur in MRL/lpr lupus-prone mice following treatment with butyrate. Butyrate supplementation ameliorated gut microbiota dysbiosis. These findings support the use of butyrate and butyrate-producing bacteria as potential treatments for SLE.
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DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
狼疮中的 T 细胞和 B 细胞信号传导生物标志物和治疗靶点。
影响因子：
5.1
作者：
Perl A;Fernandez DR;Telarico T;Doherty E;Francis L;Phillips PE
通讯作者：
Phillips PE
影响因子：
3.3
作者：
Cao, Tengli;Zhang, Xiuxiu;Muhammad, Abbas
通讯作者：
Muhammad, Abbas
影响因子：
6.4
作者：
Neuman, Hadar;Mor, Hadar;Koren, Omry
通讯作者：
Koren, Omry
影响因子：
3.7
作者：
Cheng, Di;Xu, Ji-Fiao;Yu, Tao
通讯作者：
Yu, Tao