Multi-component extracellular matrices based on peptide self-assembly.

Multi-component extracellular matrices based on peptide self-assembly.
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DOI:
10.1039/b914337h
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发表时间:
2010-09
影响因子:
46.2
通讯作者:
Jung JP
Jung JP
中科院分区:
化学1区
文献类型:
--
作者:
Collier JH;Rudra JS;Gasiorowski JZ;Jung JP

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细胞外基质(ECM)是材料合成的具有挑战性的设计目标,因为它们具有多种生物学作用,并且它们由多种分子成分组成。此外,它们的组成和活动是动态的,在组织之间是可变的,并且它们很难在生理背景下进行机械研究。然而,合成ECM的设计是再生医学和3D细胞培养等应用的核心考虑因素。为了生产具有多组分结构和高水平组成定义的合成基质,基于分子自组装的策略正受到越来越多的关注。这些方法在这里进行了描述,并与作为其灵感的本地ECM中的结构和过程进行了比较。
Extracellular matrices (ECMs) are challenging design targets for materials synthesis because they serve multiple biological roles, and they are composed of multiple molecular constituents. In addition, their composition and activities are dynamic and variable between tissues, and they are difficult to study mechanistically in physiological contexts. Nevertheless, the design of synthetic ECMs is a central consideration in applications such as regenerative medicine and 3D cell culture. In order to produce synthetic matrices having both multi-component construction and high levels of compositional definition, strategies based on molecular self-assembly are receiving increasing interest. These approaches are described here and compared with the structures and processes in native ECMs that serve as their inspiration.
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