Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.
Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.
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DOI：
10.1016/j.ijheh.2016.01.005
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发表时间：
2016-05
影响因子：
6
通讯作者：
Scinicariello F
中科院分区：
文献类型：
--
作者：
Buser MC;Ingber SZ;Raines N;Fowler DA;Scinicariello F
镉(Cd)和铅(Pb)是广泛存在的环境污染物，是已知的肾毒素。然而，它们在低环境暴露水平下的肾毒性作用仍存在争议。检测血铅(B-Pb)、血镉(B-Cd)、尿铅(U-Pb)和尿镉(U-Cd)与估计肾小球滤过率(EGFR)和尿白蛋白(ALB)的关系。我们使用多元线性回归分析了2007年至2012年参加NHANES2007-2012年的成年受试者(20岁的≥)B-铅、B-镉、U-铅和U-Cd与表皮生长因子受体和白蛋白的关系。该数据集仅限于有血液和尿液金属测量的NHANES个体。我们发现EGFR和B-CD之间存在统计学上显著的负相关，而EGFR与U-CD和U-Pb之间存在统计学上显著的正相关，ALB与U-CD的第三和第四个四分位数之间也存在统计学上的显著关联。EGFR和B-CD之间的负相关，以及EGFR和ALB与U-CD之间的正相关，提示低水平暴露下U-CD的测量可能是由于肾功能和蛋白质排泄导致肾脏镉排泄的变化所致。然而，这一横断面设计不能排除诸如镉介导的肾损害的高滤过或肌酐特异性的镉效应等肾脏效应。
Cadmium (Cd) and lead (Pb) are widespread environmental contaminants that are known nephrotoxins. However, their nephrotoxic effects at low-environmental exposure levels are debated. We examined the association of blood Pb (B-Pb), blood Cd (B-Cd), urinary Pb (U-Pb) and urinary Cd (U-Cd) with estimated glomerular filtration rate (eGFR) and urinary albumin (ALB). We used multivariate linear regression to analyze the association between B-Pb, B-Cd, U-Pb, and U-Cd with eGFR and ALB in adult participants (≥20 years of age) in NHANES 2007–2012. The dataset was limited to NHANES individuals with both blood and urinary metal measurements. We found a statistically significant inverse association between eGFR and B-Cd and statistically significant positive associations between eGFR and both U-Cd and U-Pb, as well as statistically significant associations between ALB and the 3rd and 4th quartiles of U-Cd. The inverse association between eGFR and B-Cd, in conjunction with positive associations between eGFR and ALB with U-Cd, suggest that U-Cd measurement at low levels of exposure may result from changes in renal excretion of Cd due to kidney function and protein excretion. However, renal effects such as hyperfiltration from Cd-mediated kidney damage or creatinine-specific Cd effects cannot be excluded with this cross-sectional design.
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影响因子：
13.2
作者：
Collins, Allan J.;Foley, Robert N.;Agodoa, Lawrence
通讯作者：
Agodoa, Lawrence
影响因子：
10.4
作者：
Akerstrom M;Sallsten G;Lundh T;Barregard L
通讯作者：
Barregard L
影响因子：
10.4
作者：
Barbosa F Jr;Tanus-Santos JE;Gerlach RF;Parsons PJ
通讯作者：
Parsons PJ
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
影响因子：
--
作者：
Fadrowski, Jeffrey J.;Navas-Acien, Ana;Tellez-Plaza, Maria;Guallar, Eliseo;Weaver, Virginia M.;Furth, Susan L.
通讯作者：
Furth, Susan L.