Epigenetic crossroads of the Epstein-Barr virus B-cell relationship.
Epigenetic crossroads of the Epstein-Barr virus B-cell relationship.
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DOI：
10.1016/j.coviro.2018.08.012
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发表时间：
2018-10
影响因子：
5.9
通讯作者：
Gewurz BE
中科院分区：
文献类型：
--
作者：
Frost TC;Gewurz BE
Epstein-Barr virus (EBV) is a gamma-herpesvirus that establishes lifelong infection in the majority of people worldwide. EBV uses epigenetic reprogramming to switch between multiple latency states in order to colonize the memory B-cell compartment and to then periodically undergo lytic reactivation upon plasma cell differentiation. This review focuses on recent advances in the understanding of epigenetic mechanisms that EBV uses to control its lifecycle and to subvert the growth and survival pathways that underly EBV-driven B-cell differentiation versus B-cell growth transformation, a hallmark of the first human tumor virus. These include the formation of viral super-enhancers that drive expression of key host dependency factors, evasion of tumor suppressor responses, prevention of plasmablast differentiation, and regulation of the B-cell lytic switch.
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影响因子：
30.3
作者：
Lieberman PM
通讯作者：
Lieberman PM
影响因子：
9.8
作者：
Altmann, Markus;Hammerschmidt, Wolfgang
通讯作者：
Hammerschmidt, Wolfgang
影响因子：
5.4
作者：
Lupey-Green LN;Caruso LB;Madzo J;Martin KA;Tan Y;Hulse M;Tempera I
通讯作者：
Tempera I
PARP1 通过结合 BZLF1 启动子来限制 Epstein Barr 病毒裂解再激活。
影响因子：
3.7
作者：
Lupey-Green LN;Moquin SA;Martin KA;McDevitt SM;Hulse M;Caruso LB;Pomerantz RT;Miranda JL;Tempera I
通讯作者：
Tempera I
影响因子：
5.4
作者：
Laichalk, LL;Thorley-Lawson, DA
通讯作者：
Thorley-Lawson, DA