EMAC, Retromer, and VSRs: do they connect?
EMAC, Retromer, and VSRs: do they connect?
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DOI：
10.1007/s00709-020-01543-8
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发表时间：
2020-11
期刊：
影响因子：
2.9
通讯作者：
Robinson DG
中科院分区：
文献类型：
--
作者：
Ivanov R;Robinson DG
真核生物在膜运输方面有许多共同的特征。这一事实有助于植物科学家根据酵母和哺乳动物的知识，提出关于植物细胞膜内运输是如何实现和调节的可测试假设。然而，当在植物细胞中发现一个新的隔室，其囊泡系链复合物位于与酵母和哺乳动物细胞中的对应物完全不同的位置时，在解释与其他运输元件可能的相互作用时需要谨慎。最近发现的EMAC （ER和微管相关室）就是例证。据推测，这个隔室是液泡分选受体（vrs）的接受者，通过“后高尔基体囊泡”从后高尔基体位置逆行运输。不幸的是，这一建议完全基于我们对酵母和哺乳动物细胞中逆转录物的了解，而没有考虑到现有的关于植物逆转录物的组成、定位和功能的文献。报告也没有提到最近关于虚拟货币贩运的相互矛盾的调查结果。在这篇简短的文章中，我们试图纠正这种情况，指出植物反转录酶可能不是由两个亚基组成的五聚体复合物：反转录酶核和分选连接蛋白。
Eukaryotic organisms share many common features in terms of endomembrane trafficking. This fact has helped plant scientists to propose testable hypotheses on how plant intracellular membrane trafficking is achieved and regulated based on knowledge from yeast and mammals. However, when a new compartment has been identified in a plant cell that has a vesicle tethering complex located at a position which is completely different to its counterpart in yeast and mammalian cells, caution is demanded when interpreting possible interactions with other trafficking elements. This is exemplified by the recently discovered EMAC (ER and microtubule-associated compartment). It has been postulated that this compartment is the recipient of vacuolar sorting receptors (VSRs) transported retrogradely via “retromer vesicles” from a post-Golgi location. Unfortunately, this suggestion was based entirely on our knowledge of retromer from yeast and mammalian cells, and did not take into account the available literature on the composition, localization, and function of the plant retromer. It also lacked reference to recent contradictory findings on VSR trafficking. In this short article, we have tried to rectify this situation, pointing out that plant retromer may not function as a pentameric complex of two subunits: the retromer core and the sorting nexins.
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DOI：
10.1083/jcb.201702137
发表时间：
2017-11-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kvainickas A;Jimenez-Orgaz A;Nägele H;Hu Z;Dengjel J;Steinberg F
通讯作者：
Steinberg F
DOI：
10.1083/jcb.201703015
发表时间：
2017-11-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Simonetti B;Danson CM;Heesom KJ;Cullen PJ
通讯作者：
Cullen PJ
影响因子：
2.9
作者：
Stierhof, York-Dieter;Viotti, Corrado;Robinson, David G.
通讯作者：
Robinson, David G.
影响因子：
64.8
作者：
Jaillais, Yvon;Fobis-Loisy, Isabelle;Gaude, Thierry
通讯作者：
Gaude, Thierry
影响因子：
11.6
作者：
Oliviusson, P;Heinzerling, O;Robinson, DG
通讯作者：
Robinson, DG