On the quantification of sample microstructure using single-exposure x-ray dark-field imaging via a single-grid setup.
On the quantification of sample microstructure using single-exposure x-ray dark-field imaging via a single-grid setup.
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DOI：
10.1038/s41598-023-37334-3
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发表时间：
2023-07-07
影响因子：
4.6
通讯作者：
Morgan, Kaye S.
中科院分区：
文献类型：
--
作者：
How, Ying Ying;Paganin, David M.;Morgan, Kaye S.
X射线成像系统中最小可检测样本特征的尺寸通常受到系统的空间分辨率的限制。这种限制现在可以克服使用扩散暗场信号，这是由未解决的相位效应或从未解决的样品微结构的超小角度X射线散射产生的。这种暗场信号的定量测量可以用于揭示用于医疗诊断、安全筛选和材料科学的微结构尺寸或材料。最近，我们推导出一种新的方法来量化的散射角方面的扩散暗场信号，使用单次曝光的网格为基础的方法。在这篇手稿中，我们看看从这个单次曝光暗场信号量化样品的微观结构尺寸的问题。我们通过量化5种不同尺寸的聚苯乙烯微球（范围从1.0到10.8 μm）产生的扩散暗场信号来实现这一点，以研究提取的暗场信号的强度如何随样品微结构尺寸而变化。我们还探讨了单次曝光暗场成像的可行性，给出了一个简单的方程的最佳传播距离，具有特定的尺寸和厚度的微结构，并显示该模型和实验数据之间的一致性。我们的理论模型预测暗场散射角与成反比，这也与我们的实验数据相一致。
The size of the smallest detectable sample feature in an x-ray imaging system is usually restricted by the spatial resolution of the system. This limitation can now be overcome using the diffusive dark-field signal, which is generated by unresolved phase effects or the ultra-small-angle x-ray scattering from unresolved sample microstructures. A quantitative measure of this dark-field signal can be useful in revealing the microstructure size or material for medical diagnosis, security screening and materials science. Recently, we derived a new method to quantify the diffusive dark-field signal in terms of a scattering angle using a single-exposure grid-based approach. In this manuscript, we look at the problem of quantifying the sample microstructure size from this single-exposure dark-field signal. We do this by quantifying the diffusive dark-field signal produced by 5 different sizes of polystyrene microspheres, ranging from 1.0 to 10.8 µm, to investigate how the strength of the extracted dark-field signal changes with the sample microstructure size, . We also explore the feasibility of performing single-exposure dark-field imaging with a simple equation for the optimal propagation distance, given microstructure with a specific size and thickness, and show consistency between this model and experimental data. Our theoretical model predicts that the dark-field scattering angle is inversely proportional to , which is also consistent with our experimental data.
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