Coupling between the Circadian Clock and Cell Cycle Oscillators: Implication for Healthy Cells and Malignant Growth.
Coupling between the Circadian Clock and Cell Cycle Oscillators: Implication for Healthy Cells and Malignant Growth.
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昼夜节律振荡器之间的耦合：对健康细胞和恶性生长的影响。
DOI：
10.3389/fneur.2015.00096
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发表时间：
2015
影响因子：
3.4
通讯作者：
Delaunay F
中科院分区：
文献类型：
--
作者：
Feillet C;van der Horst GT;Levi F;Rand DA;Delaunay F
不受控制的细胞增殖是导致癌症的关键特征之一。时间生物学的开创性工作表明，无论是通过手术、遗传还是环境操作，扰乱小鼠的昼夜节律系统，都会增加肿瘤的发展。在人类中，倒班工作是癌症的风险因素。基于这些观察，生物钟和细胞周期之间的联系变得直观起来。但是，尽管发现了这两个过程之间的分子联系，但时钟对细胞周期动力学的影响从未被正式观察到。最近，两项结合单个活细胞成像和计算方法的研究揭示了时钟和细胞周期振荡器之间的强大耦合。我们在这里总结了这些新的发现，并将它们与早期在健康和癌细胞中的结果进行了整合。此外，我们认为细胞周期可以通过与生物钟的耦合而同步或减慢，从而导致肿瘤生长减少。系统生物学比以往任何时候都更有助于理解生物钟和细胞周期之间的动态相互作用，这在细胞协调和癌症等疾病中至关重要。
Uncontrolled cell proliferation is one of the key features leading to cancer. Seminal works in chronobiology have revealed that disruption of the circadian timing system in mice, either by surgical, genetic, or environmental manipulation, increased tumor development. In humans, shift work is a risk factor for cancer. Based on these observations, the link between the circadian clock and cell cycle has become intuitive. But despite identification of molecular connections between the two processes, the influence of the clock on the dynamics of the cell cycle has never been formally observed. Recently, two studies combining single live cell imaging with computational methods have shed light on robust coupling between clock and cell cycle oscillators. We recapitulate here these novel findings and integrate them with earlier results in both healthy and cancerous cells. Moreover, we propose that the cell cycle may be synchronized or slowed down through coupling with the circadian clock, which results in reduced tumor growth. More than ever, systems biology has become instrumental to understand the dynamic interaction between the circadian clock and cell cycle, which is critical in cellular coordination and for diseases such as cancer.
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影响因子：
4
作者：
Dong, Guogang;Kim, Yong-Ick;Golden, Susan S.
通讯作者：
Golden, Susan S.
癌症发展和治疗中的生物钟。
DOI：
10.1016/b978-0-12-396971-2.00009-9
发表时间：
2013
影响因子：
--
作者：
Fu, Loning;Kettner, Nicole M.
通讯作者：
Kettner, Nicole M.
DOI：
10.1016/j.mrgentox.2009.10.002
发表时间：
2009-11-01
影响因子：
1.9
作者：
Filipski, Elisabeth;Subramanian, Perumal;Levi, Francis
通讯作者：
Levi, Francis
影响因子：
11.2
作者：
Gauger, MA;Sancar, A
通讯作者：
Sancar, A
影响因子：
4.3
作者：
Antoch, Marina P.;Gorbacheva, Victoria Y.;Nikitin, Alexander Yu
通讯作者：
Nikitin, Alexander Yu