Simplicity and complexity in the cyanobacterial circadian clock mechanism.

Simplicity and complexity in the cyanobacterial circadian clock mechanism.
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DOI:
10.1016/j.gde.2010.09.002
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发表时间:
2010-12
影响因子:
4
通讯作者:
Golden, Susan S.
Golden, Susan S.
中科院分区:
生物学2区
文献类型:
--
作者:
Dong, Guogang;Kim, Yong-Ick;Golden, Susan S.

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The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.
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