Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages.
Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages.
复制标题
小鼠长期摄入乙醇会增加活化巨噬细胞的 CD80 和 CD86 表达。
DOI：
10.1016/j.alcohol.2004.01.004
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Cook,RobertT
中科院分区：
文献类型：
--
作者：
Zhu,Xiaoyan;Coleman,RuthA;Alber,Carol;Ballas,ZuhairK;Waldschmidt,ThomasJ;Ray,NancyB;Krieg,ArthurM;Cook,RobertT
Results from previous studies from our laboratory have shown that T cells obtained from the spleens of C57BL/6 mice that consumed ethanol chronically have increased expression of activation markers and increased second signal–independent production of interferon-gamma (IFN-γ). We now report that in vitro–activated CD11b+splenocytes obtained from C57BL/6 and BALB/c mice that consumed ethanol chronically express increased levels of the T cell co-stimulatory molecules CD80 and CD86. CD11b+splenocytes encompass at least two populations: the CD11b+Gr.1−population, which is primarily monocytes–macrophages, and a smaller CD11b+Gr.1+population, which is in the myelocytic–monocytic cell series and contains precursors of both macrophages and neutrophils. Evaluation of cultures of purified CD11b+cells, obtained from mice that consumed ethanol chronically, incubated overnight, showed increased up-regulation of CD80 and CD86 expression on Gr.1−mouse splenic macrophages. Results of functional studies of purified CD11b+cells have demonstrated that CD11b+cells obtained from C57BL/6 mice that were exposed to ethanol chronically secrete higher levels, in comparison with the levels secreted by CD11b+cells obtained from control animals, of nitric oxide and several proinflammatory cytokines after stimulation by the oligodeoxynucleotide (ODN) CpG 1826. These findings indicate that CD11b+splenocytes are in some way sensitized to activating stimuli by chronic ethanol exposure in vivo. Such cells may contribute to systemic immunodysregulation, including T-cell activation, by providing abnormal second signals to T cells, or through excessive release of cytokines, such as interleukin (IL)-6 or IL-12.
登录
查看更多内容
影响因子：
11.2
作者：
R. Delorenzo
通讯作者：
R. Delorenzo
二苯妥英（苯妥英）对培养的成骨细胞样细胞离子转运 ATP 酶的直接影响
影响因子：
5.6
作者：
Richard E. Anderson;D. M. Woodbury
通讯作者：
D. M. Woodbury
二苯乙内酰脲抑制甲状旁腺激素和前列腺素 E2 刺激的小鼠颅骨骨吸收，而不影响环 AMP 形成。
DOI：
--
发表时间：
1985
期刊：
Journal of oral pathology
影响因子：
--
作者：
U. Lerner;B. Fredholm;L. Hänström
通讯作者：
L. Hänström
二苯乙内酰脲和苯巴比妥对大鼠肠道钙转运的影响*
影响因子：
5.6
作者：
H. Koch;D. Kraft;D. Herrath;K. Schaefer
通讯作者：
K. Schaefer
分离骨细胞中的钙转运。
影响因子：
4.8
作者：
R. Dziak;P. Stern
通讯作者：
P. Stern