MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines.
MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines.
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迷走神经可通过巨噬细胞上的α7-烟碱乙酰胆碱受体（α 7 nAChR）介导的胆碱能抗炎通路控制炎症反应。然而，联系α 7 nAChR激活和促炎细胞因子产生的细胞内机制仍然没有很好的理解。在这项研究中，我们发现miR-124在LPS暴露的细胞和小鼠中被胆碱能激动剂上调。利用miR-124模拟物和siRNA敲低，我们证明了miR-124是胆碱能抗炎作用的关键介质。此外，我们的数据表明，miR-124通过靶向信号转导子和转录激活子3（STAT 3）来调节LPS诱导的细胞因子产生，以减少IL-6的产生和TNF-α转化酶（TACE），以减少TNF-α的释放。这些结果也表明miR-124是治疗炎症性疾病的潜在治疗靶点。
The vagus nerve can control inflammatory response through a 'cholinergic anti-inflammatory pathway', which is mediated by the α7-nicotinic acetylcholine receptor (α7nAChR) on macrophages. However, the intracellular mechanisms that link α7nAChR activation and pro-inflammatory cytokine production remain not well understood. In this study, we found that miR-124 is upregulated by cholinergic agonists in LPS-exposed cells and mice. Utilizing miR-124 mimic and siRNA knockdown, we demonstrated that miR-124 is a critical mediator for the cholinergic anti-inflammatory action. Furthermore, our data indicated that miR-124 modulates LPS-induced cytokine production by targeting signal transducer and activator of transcription 3 (STAT3) to decrease IL-6 production and TNF-α converting enzyme (TACE) to reduce TNF-α release. These results also indicate that miR-124 is a potential therapeutic target for the treatment of inflammatory diseases.
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影响因子：
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作者：
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