Endodermal stem cell populations derived from pluripotent stem cells.
Endodermal stem cell populations derived from pluripotent stem cells.
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DOI:
10.1016/j.ceb.2013.01.006
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发表时间:
2013-04
影响因子:
7.5
通讯作者:
Gadue, Paul
中科院分区:
文献类型:
--
作者:
Cheng, Xin;Tiyaboonchai, Amita;Gadue, Paul
The generation of functional endodermal lineages, such as hepatocytes and pancreatic endocrine cells, from pluripotent stem cells remains a challenge. One strategy to enhance the purity, yield and maturity of endodermal derivatives is to expand endoderm committed stem or progenitor cell populations derived from pluripotent stem cells prior to final differentiation. Recent studies have shown that this is in fact a viable option both for expanding pure populations of endodermal cells as well as for generating more mature derivative tissues, as highlighted in the case of pancreatic beta cells.
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