Endodermal stem cell populations derived from pluripotent stem cells.

Endodermal stem cell populations derived from pluripotent stem cells.
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DOI:
10.1016/j.ceb.2013.01.006
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发表时间:
2013-04
影响因子:
7.5
通讯作者:
Gadue, Paul
Gadue, Paul
中科院分区:
生物学2区
文献类型:
--
作者:
Cheng, Xin;Tiyaboonchai, Amita;Gadue, Paul

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从多能干细胞产生功能性内胚层谱系,例如肝细胞和胰腺内分泌细胞仍然是一个挑战。提高内胚层衍生物的纯度、产量和成熟度的一种策略是在最终分化之前扩大源自多能干细胞的内胚层定向干细胞或祖细胞群。最近的研究表明,这实际上是一种可行的选择,既可以用于扩大内胚层细胞的纯群体,也可以用于产生更成熟的衍生组织,正如胰腺β细胞的情况所强调的那样。
The generation of functional endodermal lineages, such as hepatocytes and pancreatic endocrine cells, from pluripotent stem cells remains a challenge. One strategy to enhance the purity, yield and maturity of endodermal derivatives is to expand endoderm committed stem or progenitor cell populations derived from pluripotent stem cells prior to final differentiation. Recent studies have shown that this is in fact a viable option both for expanding pure populations of endodermal cells as well as for generating more mature derivative tissues, as highlighted in the case of pancreatic beta cells.
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