An evaluation and replication of miRNAs with disease stage and colorectal cancer-specific mortality.
An evaluation and replication of miRNAs with disease stage and colorectal cancer-specific mortality.
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具有疾病期和结直肠癌特异性死亡率的miRNA的评估和复制。
DOI：
10.1002/ijc.29384
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发表时间：
2015-07-15
影响因子：
6.4
通讯作者：
Wolff, Roger K.
中科院分区：
文献类型：
--
作者：
Slattery, Martha L.;Herrick, Jennifer S.;Mullany, Lila E.;Valeri, Nicola;Stevens, John;Caan, Bette J.;Samowitz, Wade;Wolff, Roger K.
MiRNAs与结直肠癌的发展有关，并与疾病分期和生存期等预后指标有关。预后关联往往建立在少数个体的基础上，而且不准确。在这项研究中，我们利用来自1141例结直肠癌(CRC)病例的基于人群的数据来复制先前报道的121个miRNAs与疾病分期和生存期之间的关联。Agilent Human miRNA微阵列V19.0用于按照严格的质量控制协议生成miRNA数据。生存评估采用COX比例风险模型，对年龄、疾病分期和肿瘤分子表型进行调整。5个miRNAs与肿瘤分期相关，hsa-miR-145-5p和hsa-miR-31-5p与肿瘤分期相关，hsa-miR-200b-3p、hsa-miR-215和hsa-miR-451a表达下调。在诊断为结肠癌的患者中，13个miRNAs与结直肠癌死亡率有关，而在诊断为直肠癌后，14个miRNAs与结直肠癌死亡率有关。观察到在一小部分肿瘤中表达的miRNAs之间存在最强的相关性。最显著的关联是hsa-miR-145-3p(HR 2.94 95%CI 1.54，5.61)和hsa-miR-9-3p(HR 10.28 95%CI 1.31 80.84)与结肠癌和hsa-miR-335-5p(HR 0.17 95%CI 0.05，0.54)与直肠癌的相关性。HSA-miR-374a-5p、hsa-miR-570-3p和hsa-miR-18a-5p显著降低了所有病例的死亡风险，无论肿瘤部位如何。我们的发现表明，需要一个大样本来评估miRNAs与生存期和疾病分期的相关性，以便确定肿瘤部位的相关性。
MiRNAs have been implicated in CRC development and associated with prognostic indicators such as disease stage and survival. Prognostic associations are often based on few individuals and imprecise. In this study, we utilize population-based data from 1141 colorectal cancer (CRC) cases to replicate previously reported associations between 121 miRNAs and disease stage and survival. The Agilent Human miRNA Microarray V19.0 was used to generate miRNA data following a stringent quality control protocol. Assessment of survival was done using Cox Proportional Hazard models adjusting for age, disease stage, and tumor molecular phenotype. Five miRNAs were associated with more advanced disease stage; hsa-miR-145-5p and hsa-miR-31-5p showed increased expression with more advanced tumor stage, while hsa-miR-200b-3p, hsa-miR-215, and hsa-miR-451a had decreased expression with more advanced tumors. Thirteen miRNAs were associated with colorectal cancer mortality among individuals diagnosed with colon cancer while fourteen were associated with colorectal cancer mortality after a diagnosis with rectal cancer. Strongest associations were observed for those miRNAs that were expressed in a small subset of tumors. Most notable associations were for hsa-miR-145-3p (HR 2.94 95% CI 1.54, 5.61), and hsa-miR-9-3p (HR 10.28 95% CI1.31 80.84) with colon cancer and hsa-miR-335-5p (HR 0.17 95% CI 0.05, 0.54) for rectal cancer. Hsa-miR-374a-5p, hsa-miR-570-3p and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of tumor site. Our findings illustrate the need for a large sample to evaluate the association of miRNAs with survival and disease stage in order to determine associations by tumor site.
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影响因子：
4.3
作者：
Oliveras-Ferraros, Cristina;Cufi, Slvia;Menendez, Javier A.
通讯作者：
Menendez, Javier A.
影响因子：
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作者：
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通讯作者：
Huang HD
影响因子：
14.9
作者：
Griffiths-Jones S;Grocock RJ;van Dongen S;Bateman A;Enright AJ
通讯作者：
Enright AJ
HMGA1 靶标 MicroRNA-137 通过直接靶向 FMNL2 抑制小鼠结直肠癌细胞侵袭和转移
影响因子：
29.4
作者：
Liang, Li;Li, Xianzheng;Ding, Yanqing
通讯作者：
Ding, Yanqing