miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions.

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions.
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DOI:
10.1093/nar/gkt1266
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发表时间:
2014-01
影响因子:
14.9
通讯作者:
Huang HD
Huang HD
中科院分区:
生物学2区
文献类型:
--
作者:
Hsu SD;Tseng YT;Shrestha S;Lin YL;Khaleel A;Chou CH;Chu CF;Huang HY;Lin CM;Ho SY;Jian TY;Lin FM;Chang TH;Weng SL;Liao KW;Liao IE;Liu CC;Huang HD

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MicroRNAs(MiRNAs)是一种非编码的小RNA分子,能够负向调节基因表达,从而控制许多细胞机制。MiRTarBase数据库(http://mirtarbase.mbc.nctu.edu.tw/))提供了经过实验验证的miRNA-靶相互作用的最新和最全面的信息。该数据库于2010年启动,数据来源为>100,发表了在miRNA靶标识别、miRNA靶标分子网络和系统生物学方面的研究,目前的版本(2013,版本4)在最初版本(2010,版本1)的基础上进行了重大扩展和增强。本文报告了数据库的现状和最近的改进,包括(I)miRNA-靶相互作用条目增加了14倍,(Ii)miRNA-靶网络,(Iii)miRNA及其靶基因的表达谱,(Iv)miRNA靶相关疾病和(V)其他实用工具,包括升级提醒和错误报告/用户反馈系统。
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.
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