A case of a long‐time survivor with chronic active Epstein–Barr virus infection
A case of a long‐time survivor with chronic active Epstein–Barr virus infection
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一例慢性活动性爱泼斯坦-巴尔病毒感染的长期幸存者病例
DOI：
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发表时间：
2004
影响因子：
3.1
通讯作者：
S. Imashuku
中科院分区：
文献类型：
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作者：
Y. Takeoka;Y. Nakao;M. Ueda;Ki‐Ryang Koh;Y. Aoyama;H. Nakamae;R. Yamamura;K. Ohta;T. Takubo;T. Yamane;M. Hino;Y. Tokura;S. Ishihara;K. Oshima;H. Kimura;S. Imashuku
EB病毒（EBV）与蚊子叮咬过敏（HMB）和致命的EBV相关噬血细胞综合征（HPS）有关。慢性活动性EBV感染（CAEBV）患者的预后非常差。我们报告了一例罕见的成年女性患者，有28年的HMB病史，发展为EBV-HPS。血清和外周血淋巴细胞中检测到EBV基因组。使用EBV基因组末端重复探针通过Southern印迹分析证明EBV的克隆增殖。这是一个非常罕见的长期生存与CAEBV的情况。患者最初接受免疫化疗，并获得完全缓解。然而，患者立即复发，并接受了来自其HLA匹配兄弟的异基因骨髓移植（BMT）。外周血细胞恢复良好，EBV基因组消失。同种异体BMT可能有效根除EBV-HPS。不幸的是，患者在BMT后第92天死于移植物抗宿主病。
Epstein–Barr virus (EBV) is associated with hypersensitivity to mosquito bites (HMB) and fatal EBV‐associated hemophagocytic syndrome (HPS). The prognosis of patients with chronic active EBV infection (CAEBV) is very poor. We report a rare case of an adult woman patient with a 28‐yr history of HMB, who developed EBV‐HPS. EBV genome was detected in the serum and peripheral blood lymphocytes. Clonal proliferation of EBV was demonstrated by Southern blot analysis using an EBV genome terminal‐repeat probe. This is a very rare case of a long‐term survivor with CAEBV. The patient was initially treated with immunochemotherapy and achieved complete remission. However, the patient immediately relapsed and underwent allogeneic bone marrow transplantation (BMT) from her HLA‐matched brother. Peripheral blood cell recovered well, and EBV genome disappeared from the peripheral blood. Allogeneic BMT may be effective in eradicating EBV‐HPS. Unfortunately, the patient died of graft vs. host disease on the 92nd day after BMT.
影响因子：
39.2
作者：
SCHOOLEY, RT;CAREY, RW;RUBIN, RH
通讯作者：
RUBIN, RH