Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.
Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.
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对中国和欧洲人群的 GWAS 荟萃分析确定 GPR173 是 SLE 的新型 X 染色体易感基因
DOI：
10.1186/s13075-018-1590-3
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发表时间：
2018-05-03
影响因子：
4.9
通讯作者：
Yang W
中科院分区：
文献类型：
--
作者：
Zhang H;Zhang Y;Wang YF;Morris D;Hirankarn N;Sheng Y;Shen J;Pan HF;Yang J;Yang S;Cui Y;Ye DQ;Vyse TJ;Zhang X;Lau YL;Yang W
研究背景系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，女性多见，尤其是育龄妇女。我们进行了分析的三个全基因组基因型数据集的人口中国和欧洲origin.MethodsThis研究涉及5695例和10,357控制在发现阶段。X染色体上的前导信号随后在另外三个亚洲队列中复制，总共有2300例病例和4244例对照。对X染色体上已知的相关位点进行条件分析，进一步探索独立信号。结果发现GPR 173单核苷酸多态性rs 13440883与SLE显著相关（Pmeta = 7.53 × 10− 9，ORmeta= 1.16），而条件分析提供了亚洲人群中L1 CAM-IRAK 1-MECP 2区域潜在独立信号的证据（rs 5987175 [LCA 10]）.结论我们在X染色体上鉴定了一个新的SLE易感基因座。
BackgroundSystemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of populations of both Chinese and European origin.MethodsThis study involved 5695 cases and 10,357 controls in the discovery stage. The lead signal on chromosome X was followed by replication in three additional Asian cohorts, with 2300 cases and 4244 controls in total. Conditional analysis of the known associated loci on chromosome X was also performed to further explore independent signals.ResultsSingle-nucleotide polymorphism rs13440883 in GPR173 was found to be significantly associated with SLE (Pmeta = 7.53 × 10− 9, ORmeta= 1.16), whereas conditional analysis provided evidence of a potential independent signal in the L1CAM-IRAK1-MECP2 region in Asian populations (rs5987175 [LCA10]).ConclusionsWe identified a novel SLE susceptibility locus on the X chromosome.
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影响因子：
9.8
作者：
ENCODE Project Consortium
通讯作者：
ENCODE Project Consortium
中国和欧洲个体的全基因组关联荟萃分析确定了与系统性红斑狼疮相关的十个新位点
影响因子：
30.8
作者：
Morris DL;Sheng Y;Zhang Y;Wang YF;Zhu Z;Tombleson P;Chen L;Cunninghame Graham DS;Bentham J;Roberts AL;Chen R;Zuo X;Wang T;Wen L;Yang C;Liu L;Yang L;Li F;Huang Y;Yin X;Yang S;Rönnblom L;Fürnrohr BG;Voll RE;Schett G;Costedoat-Chalumeau N;Gaffney PM;Lau YL;Zhang X;Yang W;Cui Y;Vyse TJ
通讯作者：
Vyse TJ
影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者：
Snyder M
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
7
作者：
Schaub MA;Boyle AP;Kundaje A;Batzoglou S;Snyder M
通讯作者：
Snyder M