Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease.
Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease.
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DOI：
10.3791/60729
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发表时间：
2020-02-18
期刊：
影响因子：
--
通讯作者：
Nguyen KL
中科院分区：
文献类型：
--
作者：
Hollowed JJ;Colbert CM;Currier JW;Nguyen KL
在大型动物中创建局灶性冠状动脉狭窄模型的微创方法具有挑战性。使用 3D 打印冠状动脉植入物进行快速原型制作可用于经皮创建局灶性冠状动脉狭窄。然而，如果不使用辅助设备，植入物的可靠输送可能会很困难。我们描述了使用母子冠状动脉引导导管来稳定植入物，并将 3D 打印植入物有效输送到沿冠状血管长度的任何所需位置。冠状动脉血管造影证实局灶性冠状动脉狭窄，并使用钆增强首过心脏灌注 MRI 评估冠状动脉狭窄的功能意义。我们证明，通过重新利用母子冠状动脉导管，可以在缺血性心脏病猪模型（N = 11）中可靠地输送 3D 打印冠状动脉植入物。我们的技术简化了冠状动脉植入物的经皮输送，以创建局灶性冠状动脉狭窄的闭胸猪模型，并且可以快速执行，操作失败率低。我们描述了一种新颖、经济且高效的技术，用于经皮输送 3D 打印冠状动脉植入物，以创建缺血性心脏病的闭胸猪模型。使用母子延长导管将种植体固定到位，成功率很高。
Minimally invasive methods for creating models of focal coronary narrowing in large animals are challenging. Rapid prototyping using 3D printed coronary implants can be employed to percutaneously create a focal coronary stenosis. However, reliable delivery of the implants can be difficult without the use of ancillary equipment. We describe the use of a mother-and-child coronary guide catheter for stabilization of the implant and for effective delivery of the 3D printed implant to any desired location along the length of the coronary vessel. The focal coronary narrowing was confirmed under coronary cineangiography and the functional significance of the coronary stenosis was assessed using gadolinium-enhanced first-pass cardiac perfusion MRI. We showed that reliable delivery of 3D printed coronary implants in swine models (N=11) of ischemic heart disease can be achieved through repurposing of mother-and-child coronary guide catheters. Our technique simplifies the percutaneous delivery of coronary implants to create closed-chest swine models of focal coronary artery stenosis and can be performed expeditiously, with a low procedural failure rate. We describe a novel, cost-effective, and efficient technique for percutaneous delivery of 3D-printed coronary implants to create closed-chest swine models of ischemic heart disease. The implants were fixed in place using a mother-and-child extension catheter with high success rate.
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影响因子：
3.3
作者：
HERR, MD;MCINERNEY, JJ;MORRIS, DL
通讯作者：
MORRIS, DL
影响因子：
39.3
作者：
Schwitter, Juerg;Wacker, Christian M.;Johansson, Lars
通讯作者：
Johansson, Lars
影响因子：
120.7
作者：
Mokdad, Ali H.;Ballestros, Katherine;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
DOI：
10.1152/ajpheart.00561.2013
发表时间：
2013-11-01
影响因子：
4.8
作者：
Rissanen, Tuomas T.;Nurro, Jussi;Yla-Herttuala, Seppo
通讯作者：
Yla-Herttuala, Seppo
影响因子：
5.7
作者：
Mahrholdt, Heiko;Klem, Igor;Sechtem, Udo
通讯作者：
Sechtem, Udo