Diffuse brain injury does not affect chronic sleep patterns in the mouse.
Diffuse brain injury does not affect chronic sleep patterns in the mouse.
复制标题
DOI：
10.3109/02699052.2014.888768
复制
发表时间：
2014
期刊：
影响因子：
1.9
通讯作者：
Lifshitz J
中科院分区：
文献类型：
--
作者：
Rowe RK;Harrison JL;O'Hara BF;Lifshitz J
To test if the current model of diffuse brain injury produces chronic sleep disturbances similar to those reported by TBI patients. Adult male C57BL/6 mice were subjected to moderate midline fluid percussion injury (n = 7; 1.4 atm; 6–10 minutes righting reflex time) or sham injury (n = 5). Sleep–wake activity was measured post-injury using a non-invasive, piezoelectric cage system. Chronic sleep patterns were analysed weekly for increases or decreases in percentage sleep (hypersomnia or insomnia) and changes in bout length (fragmentation). During the first week after diffuse TBI, brain-injured mice exhibited increased mean percentage sleep and mean bout length compared to sham-injured mice. Further analysis indicated the increase in mean percentage sleep occurred during the dark cycle. Injury-induced changes in sleep, however, did not extend beyond the first week post-injury and were not present in weeks 2–5 post-injury. Previously, it has been shown that the midline fluid percussion model used in this study immediately increased post-traumatic sleep. The current study extended the timeline of investigation to show that sleep disturbances extended into the first week post-injury, but did not develop into chronic sleep disturbances. However, the clinical prevalence of TBI-related sleep–wake disturbances warrants further experimental investigation.
登录
查看更多内容
DOI：
10.1523/jneurosci.1423-10.2010
发表时间：
2010-06-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dworak M;McCarley RW;Kim T;Kalinchuk AV;Basheer R
通讯作者：
Basheer R
影响因子：
3.8
作者：
Kaufman, Y;Tzischinsky, O;Pillar, G
通讯作者：
Pillar, G
影响因子：
2.8
作者：
KRUEGER, JM;MAJDE, JA
通讯作者：
MAJDE, JA
影响因子：
4.8
作者：
Dalgard CL;Cole JT;Kean WS;Lucky JJ;Sukumar G;McMullen DC;Pollard HB;Watson WD
通讯作者：
Watson WD
影响因子：
2.8
作者：
Krueger, James M.;Rector, David M.;Churchill, Lynn
通讯作者：
Churchill, Lynn