Changes in the macrophage population of the rat superior cervical ganglion after postganglionic nerve injury.
Changes in the macrophage population of the rat superior cervical ganglion after postganglionic nerve injury.
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节后神经损伤后大鼠颈上神经节巨噬细胞群的变化
DOI：
10.1002/neu.480270203
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Zigmond,RE
中科院分区：
文献类型：
--
作者：
Schreiber,RC;Shadiack,AM;Bennett,TA;Sedwick,CE;Zigmond,RE
周围神经横断后，损伤部位及远端轴突和雪旺细胞发生一系列生化变化。巨噬细胞从单核细胞分化而来，在横断反应中侵入该区域（诱导的巨噬细胞），也许，正常存在于组织中的巨噬细胞（常驻巨噬细胞）也在这些变化中起重要作用。此外，神经横断使离病灶一定距离的被切开神经元的细胞体及其周围的胶质细胞发生改变。为了确定巨噬细胞是否可能在轴突切开后颈上神经节（SCG）发生的变化中发挥作用，我们检测了轴突损伤前后巨噬细胞的存在。使用单克隆抗体ED1， ED2和OX6，每个抗体识别不同的巨噬细胞群。正常大鼠的神经节中含有大量ED2+的常驻细胞，但很少有ED1+的。切断节后神经后2天内，ED1+细胞数量明显增加，ED2免疫染色变化不大。这些数据，结合已发表的关于其他组织的研究，表明SCG中的ED1对诱导的巨噬细胞具有选择性，ED2对常驻巨噬细胞具有选择性。OX6免疫染色在正常神经节中比较突出，但在截轴后也明显增加，提示它反映了两种巨噬细胞的数量。全身给药6 -羟多巴胺（一种导致交感神经末梢破坏的神经毒素）也会导致ED1免疫染色增加。因此，SCG中ED1免疫染色的改变不需要手术，也不需要切除局部血管和结缔组织，只需要切断交感神经元与其最终器官的连接。轴切术后单核细胞入侵的时间过程表明，这一过程并不需要触发最初24小时内神经节发生的生化变化。另一方面，巨噬细胞常驻群体的存在提高了这些细胞变化可能参与的可能性。©1995 John Wiley & Sons, Inc
Following peripheral nerve transection, a series of biochemical changes occurs in axons and Schwann cells both at the site of lesion and distal to it. Macrophages differentiated from monocytes that invade the area in response to transection (elicited macrophages) and, perhaps, also macrophages normally present in the tissue (resident macrophages) play important roles in these changes. In addition, nerve transection produces changes in the cell bodies of axotomized neurons and their surrounding glial cells, located at some distance from the lesion. To determine whether macrophages might play a role in the changes occurring in the superior cervical ganglion (SCG) after axotomy, we examined the presence of macrophages before and after axonal damage. The monoclonal antibodies ED1, ED2, and OX6 were used, each of which recognizes a somewhat different population of macrophages. Ganglia from normal rats contained a population of resident cells that were ED2+ but very few that were ED1+. Within 2 days after the postganglionic nerves were transected, the number of ED1+ cells increased substantially, with little change in immunostaining for ED2. These data, in combination with published studies on other tissues, suggest that ED1 in the SCG is selective for elicited macrophages and ED2 for resident macrophages. OX6 immunostaining was prominent in normal ganglia but also increased significantly after axotomy, suggesting that it reflects both macrophage populations. Systemic administration of 6‐hydroxydopamine, a neurotoxin that causes the destruction of sympathetic nerve endings, also produced an increase in ED1 immunostaining. Thus, the change in ED1 immunostaining in the SCG does not require surgery, with the attendant servering of local blood vessels and connective tissue, but rather only the disconnection of sympathetic neurons from their end organs. The time course of the invasion of monocytes after axotomy indicates that this process is not required to trigger the biochemical changes occurring in the ganglion within the first 24 h. On the other hand, the existence of a resident population of macrophages raises the possibility that changes in those cells might be involved. © 1995 John Wiley & Sons, Inc.
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影响因子：
3.3
作者：
BERGSTEINSDOTTIR, K;KINGSTON, A;JESSEN, KR
通讯作者：
JESSEN, KR
巨噬细胞和神经系统。
DOI：
10.1016/s0074-7696(08)61220-6
发表时间：
1994
期刊：
International review of cytology
影响因子：
--
作者：
V. Perry;S. Gordon
通讯作者：
S. Gordon
脂多糖通过神经节白细胞介素 1 的产生诱导交感神经节中的 P 物质
影响因子：
3.3
作者：
Annette M. Shadiak;Christopher D. Carlson;M. Ding;R. Hart;G. Jonakait
通讯作者：
G. Jonakait
DOI：
10.1002/neu.480250407
发表时间：
1994-04-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
SUN, Y;RAO, MS;LANDIS, SC
通讯作者：
LANDIS, SC
在节后轴突切断术引起的突触传递抑制过程中，结构完整的神经末梢与大鼠颈上神经节的溶色神经元分离。
DOI：
--
发表时间：
1975
期刊：
Journal of Physiology
影响因子：
--
作者：
M. Matthews;V. Nelson
通讯作者：
V. Nelson