Adherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis.
Adherence to Nucleos(t)ide Analogue Therapies for Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis.
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DOI：
10.1002/hep4.1247
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发表时间：
2018-10
影响因子：
5.1
通讯作者：
Wandeler G
中科院分区：
文献类型：
--
作者：
Ford N;Scourse R;Lemoine M;Hutin Y;Bulterys M;Shubber Z;Donchuk D;Wandeler G
慢性乙型肝炎病毒 (HBV) 感染的成功治疗结果需要高度坚持治疗。我们检索了截至 2018 年 1 月的三个数据库和两个会议的摘要，以查找报告坚持 HBV 抗病毒治疗的患者比例的研究，并使用随机效应荟萃分析汇总数据。我们纳入了 30 项研究，为 23,823 名患者提供数据。总体而言，治疗依从率为 74.6%（95% 置信区间 [CI] 67.1%‐82.1%）。高收入环境（75.1%；95% CI，65.4%‐85.0%）以及低收入和中等收入环境（72.9%；95% CI，57.8%‐88.0%）的依从性相似。据报告，坚持的障碍包括遗忘、对坚持重要性的理解有限以及改变常规。结论：需要加强对依从性的评估和报告，将其作为 HBV 护理的常规部分，并评估用于提高人类免疫缺陷病毒 [HIV] 和其他慢性疾病药物治疗依从性的循证干预措施对 HBV 感染的有效性程度。
Successful treatment outcomes for chronic hepatitis B virus (HBV) infection requires high levels of adherence to treatment. We searched three databases and abstracts from two conferences up to January 2018 for studies reporting the proportion of patients who were adherent to HBV antiviral therapy and pooled data using random effects meta‐analysis. We included 30 studies, providing data for 23,823 patients. Overall, adherence to treatment was 74.6% (95% confidence interval [CI] 67.1%‐82.1%). Adherence was similar in high‐income settings (75.1%; 95% CI, 65.4%‐85.0%) and in low‐income and middle‐income settings (72.9%; 95% CI, 57.8%‐88.0%). Reported barriers to adherence included forgetting, limited understanding of the importance of adherence, and change to routine. Conclusion: There is a need to reinforce assessment and reporting of adherence as a routine part of HBV care and to assess the extent to which evidence‐based interventions to improve adherence to medication for human immunodeficiency virus [HIV] and other chronic diseases are effective for HBV infection.
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影响因子：
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