Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function.
Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function.
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离子通道伙伴关系：控制神经元离子通道功能的奇偶和非奇偶。
DOI：
10.3390/ijms23041953
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发表时间：
2022-02-10
影响因子：
5.6
通讯作者：
Trimmer JS
中科院分区：
文献类型：
--
作者：
Vierra NC;Trimmer JS
包括脑神经细胞在内的可兴奋细胞中表达的大量离子通道协同作用，通过控制膜的电学特性来形成各种信号事件。人们早就认识到，特定的离子通道群在介导影响膜电位的离子通量中具有功能偶联，并且这些膜电位的变化影响离子通道门控。最近的研究已经确定了不同的离子通道，这些离子通道也可以在物理和功能上相互关联，以调节任何一个离子通道伴侣的功能，而不仅仅是膜电位的变化。在这里，我们回顾了这种离子通道伙伴关系的典型例子，其中Ca2+通道与Ca2+激活的K+通道合作，为Ca2+内流到K+通道激活的有效耦合提供了专用路线。我们还强调了Ca2+通道和电压门控K+通道之间的非规范离子通道伙伴关系的例子，这些通道本质上不是Ca2+敏感的，但其伙伴关系仍然产生了一个或另一个离子通道伙伴的增强调节。我们还讨论了这些离子通道伙伴关系是如何被发现它们的亚细胞区室塑造的，并提供了关于在天然细胞中识别彼此接近的蛋白质的技术的最新进展如何导致对其他离子通道伙伴关系的扩展知识的观点。
The concerted function of the large number of ion channels expressed in excitable cells, including brain neurons, shapes diverse signaling events by controlling the electrical properties of membranes. It has long been recognized that specific groups of ion channels are functionally coupled in mediating ionic fluxes that impact membrane potential, and that these changes in membrane potential impact ion channel gating. Recent studies have identified distinct sets of ion channels that can also physically and functionally associate to regulate the function of either ion channel partner beyond that afforded by changes in membrane potential alone. Here, we review canonical examples of such ion channel partnerships, in which a Ca2+ channel is partnered with a Ca2+-activated K+ channel to provide a dedicated route for efficient coupling of Ca2+ influx to K+ channel activation. We also highlight examples of non-canonical ion channel partnerships between Ca2+ channels and voltage-gated K+ channels that are not intrinsically Ca2+ sensitive, but whose partnership nonetheless yields enhanced regulation of one or the other ion channel partner. We also discuss how these ion channel partnerships can be shaped by the subcellular compartments in which they are found and provide perspectives on how recent advances in techniques to identify proteins in close proximity to one another in native cells may lead to an expanded knowledge of other ion channel partnerships.
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影响因子：
48
作者：
Bar DZ;Atkatsh K;Tavarez U;Erdos MR;Gruenbaum Y;Collins FS
通讯作者：
Collins FS
影响因子：
5.3
作者：
Anderson, Dustin;Engbers, Jordan D. T.;Turner, Ray W.
通讯作者：
Turner, Ray W.
影响因子：
25
作者：
Allen, Duane;Bond, Chris T.;Lujan, Rafael;Ballesteros-Merino, Carmen;Lin, Mike T.;Wang, Kang;Klett, Nathan;Watanabe, Masahiko;Shigemoto, Ryuichi;Stackman, Robert W., Jr.;Maylie, James;Adelman, John P.
通讯作者：
Adelman, John P.
影响因子：
7.7
作者：
Dixon RE;Moreno CM;Yuan C;Opitz-Araya X;Binder MD;Navedo MF;Santana LF
通讯作者：
Santana LF
影响因子：
3.3
作者：
Antonucci, DE;Lim, ST;Trimmer, JS
通讯作者：
Trimmer, JS