Sistema imunitário: Parte I. Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória
Sistema imunitário: Parte I. Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória
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免疫系统：第一部分。
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Luís Eduardo Coelho Andrade
中科院分区：
文献类型：
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作者：
W. Cruvinel;Danilo Mesquita Júnior;Júlio Pereira de Araújo;T. T. T. Catelan;Alexandre Silva Souza;N. Silva;Luís Eduardo Coelho Andrade
免疫系统由一个复杂的器官、细胞和分子网络组成，负责维持身体的内稳态，并对攻击做出反应。先天免疫与适应性免疫协同作用，其特点是对攻击的快速反应，无论先前的刺激如何，都是生物体的第一道防线。其机制包括物理、化学和生物屏障、细胞成分以及可溶性分子。机体抵御组织损伤的第一道防线包括由该系统的不同组成部分紧密结合并构成的几个步骤。这篇综述的目的是恢复这种反应的基础，它具有高度复杂性，由几个组成部分组成，这些组成部分汇聚在一起，阐明适应性免疫反应的发展。我们选择以下几个步骤来回顾：侵袭性药物的感知和分子识别；细胞内通路的激活，导致血管和组织的改变；产生对细胞活化和增殖具有局部和全身影响的无数介质，合成参与化学吸引和细胞迁移的新产物，专门用于破坏和去除有害物质；最后，组织恢复，恢复功能组织或器官。
The immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. Innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. Its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. The organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. The aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. We selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ.
影响因子：
20.3
作者：
T. Carlos;J. Harlan
通讯作者：
T. Carlos;J. Harlan