A highly conserved family of inactivated archaeal B family DNA polymerases.

A highly conserved family of inactivated archaeal B family DNA polymerases.
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DOI:
10.1186/1745-6150-3-32
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发表时间:
2008-08-06
期刊:
影响因子:
5.5
通讯作者:
Koonin EV
Koonin EV
中科院分区:
生物学2区
文献类型:
--
作者:
Rogozin IB;Makarova KS;Pavlov YI;Koonin EV

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一个广泛的和高度保守的家庭显然失活的衍生物古细菌B家族DNA聚合酶的描述。系统发育分析表明,灭活形式包括一个独特的进化枝之间的古细菌B-家族聚合酶,并在这个进化枝,广古菌和Crenarchea是明确分开的彼此和一小群细菌同源物。这些发现与DNA聚合酶基因的古老重复,随后在一些谱系中失活和平行丢失是相容的,尽管不能排除水平基因转移的贡献。古细菌DNA聚合酶的失活衍生物可以与活性蛋白形成复合物,并在DNA复制中发挥结构作用。本文由Purificacion Lopez-Garcia和Chris Ponting审阅。有关完整的评论,请访问评论者报告部分。
A widespread and highly conserved family of apparently inactivated derivatives of archaeal B-family DNA polymerases is described. Phylogenetic analysis shows that the inactivated forms comprise a distinct clade among archaeal B-family polymerases and that, within this clade, Euryarchaea and Crenarchaea are clearly separated from each other and from a small group of bacterial homologs. These findings are compatible with an ancient duplication of the DNA polymerase gene followed by inactivation and parallel loss in some of the lineages although contribution of horizontal gene transfer cannot be ruled out. The inactivated derivative of the archaeal DNA polymerase could form a complex with the active paralog and play a structural role in DNA replication. This article was reviewed by Purificacion Lopez-Garcia and Chris Ponting. For the full reviews, please go to the Reviewers' Reports section.
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发表时间: 2004-04-01
影响因子: 14.9
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