A highly conserved family of inactivated archaeal B family DNA polymerases.
A highly conserved family of inactivated archaeal B family DNA polymerases.
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DOI:
10.1186/1745-6150-3-32
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发表时间:
2008-08-06
期刊:
影响因子:
5.5
通讯作者:
Koonin EV
中科院分区:
文献类型:
--
作者:
Rogozin IB;Makarova KS;Pavlov YI;Koonin EV
A widespread and highly conserved family of apparently inactivated derivatives of archaeal B-family DNA polymerases is described. Phylogenetic analysis shows that the inactivated forms comprise a distinct clade among archaeal B-family polymerases and that, within this clade, Euryarchaea and Crenarchaea are clearly separated from each other and from a small group of bacterial homologs. These findings are compatible with an ancient duplication of the DNA polymerase gene followed by inactivation and parallel loss in some of the lineages although contribution of horizontal gene transfer cannot be ruled out. The inactivated derivative of the archaeal DNA polymerase could form a complex with the active paralog and play a structural role in DNA replication. This article was reviewed by Purificacion Lopez-Garcia and Chris Ponting. For the full reviews, please go to the Reviewers' Reports section.
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