CD34+ cell dose predicts relapse and survival after T-cell-depleted HLA-identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies.
CD34+ cell dose predicts relapse and survival after T-cell-depleted HLA-identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies.
复制标题
CD34 细胞剂量可预测血液恶性肿瘤 T 细胞耗尽 HLA 一致造血干细胞移植 (HSCT) 后的复发和生存。
DOI：
10.1046/j.1365-2141.2000.01838.x
复制
发表时间：
2000
影响因子：
6.5
通讯作者：
Barrett,AJ
中科院分区：
文献类型：
--
作者：
Bahceci,E;Read,EJ;Leitman,S;Childs,R;Dunbar,C;Young,NS;Barrett,AJ
Seventy‐eight patients with haematological malignancies, received T‐cell‐depleted stem cell transplants and cyclosporin followed by delayed add‐back of donor lymphocytes to prevent leukaemia relapse. The source of stem cells was bone marrow in 50 patients and granulocyte colony‐stimulating factor (G‐CSF)‐mobilized peripheral blood in 28 patients. In univariate analysis, only the CD34+ cell dose (but not the stem cell source or the T lymphocyte dose) and disease status were predictive for transplant‐related mortality, relapse and survival. Patients receiving ≥ 3 × 106CD34+ cells/kg had an overall actuarial survival of 68% compared with 52%, 35% and 10%, respectively, for cell doses of 2–2.99, 1–1.99 and < 1 × 106/kg. Multivariate analysis of risk factors for relapse identified disease risk and CD34+ cell dose as the only factors. Relapse was 62.5% in 38 patients at high risk of relapse vs. 25% for 40 patients at intermediate or low risk. CD34+ cell doses of ≥ 3 × 106/kg were associated with a 13.5% relapse vs. 48% for recipients of lower doses. This favourable effect of CD34+ cell dose on relapse was apparent in both high‐ and intermediate‐ plus low‐risk groups. Our results support the potential benefit of a high stem cell dose in lowering transplant‐related mortality (TRM) and in reducing relapse after allogeneic marrow or blood stem cell transplants.
登录
查看更多内容
影响因子：
3.1
作者：
GREEN, DM
通讯作者：
GREEN, DM
蒲公英（普通蒲公英；菊科）双孢子染色体区域的遗传连锁图
影响因子：
5.4
作者：
K. Vijverberg;R. Hulst;P. Lindhout;P. J. V. Dijk
通讯作者：
P. J. V. Dijk
无融合生殖的光明前景
DOI：
--
发表时间：
1998
期刊：
影响因子：
--
作者：
U. Grossniklaus;A. Koltunow;M. V. L. Campagne
通讯作者：
M. V. L. Campagne
影响因子：
2.6
作者：
Comai, L;Tyagi, AP;Lysak, MA
通讯作者：
Lysak, MA
影响因子：
7.4
作者：
THOMA, S;HECHT, U;SOMERVILLE, C
通讯作者：
SOMERVILLE, C