The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response.
The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response.
复制标题
鲍曼尼杆菌的囊囊可预防先天的免疫反应。
DOI：
10.1159/000522232
复制
发表时间：
2022
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
鲍曼不动杆菌是一种机会性病原体，最近已成为一种全球威胁，与高发病率、死亡率和抗生素耐药性有关。我们确定了I型干扰素（IFN）信号在鲍曼不动杆菌感染中的作用。我们报道鲍曼不动杆菌可以诱导依赖于TLR4-TRIF-IRF3和细菌吞噬的I型IFN反应。鲍曼不动杆菌的相变异具有减少的胶囊，导致增强的tlr4依赖性I型IFN诱导。这在缺乏胶囊的菌株中也观察到。然而，我们没有观察到这种途径在体内的作用。信号传导的增强可能是由于荚膜缺陷菌株的吞噬作用增加，这也导致宿主细胞介导的杀伤增强。在没有胶囊的情况下，细胞因子反应的增加并不仅限于I型IFN信号传导。几种细胞因子，包括促炎IL-6，在受胶囊缺陷菌株刺激的细胞中增加，也在体内观察到。在我们的急性肺炎模型中，4小时后，无胶囊菌株的负担显著减轻，但我们观察到与野生型鲍曼不动杆菌相比，先天免疫细胞和炎症标志物增加。本研究强调了相位变化在宿主免疫应答调节中的作用，表明鲍曼不动杆菌荚膜在防止宿主细胞杀伤和逃避先天免疫应答激活方面起着重要作用。
Acinetobacter baumannii is an opportunistic pathogen that has recently emerged as a global threat associated with high morbidity, mortality, and antibiotic resistance. We determined the role of type I interferon (IFN) signaling in A. baumannii infection. We report that A. baumannii can induce a type I IFN response that is dependent upon TLR4-TRIF-IRF3 and phagocytosis of the bacterium. Phase variants of A. baumannii that have a reduced capsule, lead to enhanced TLR4-dependent type I IFN induction. This was also observed in a capsule-deficient strain. However, we did not observe a role for this pathway in vivo. The enhanced signaling could be accounted for by increased phagocytosis in capsule-deficient strains that also lead to enhanced host cell-mediated killing. The increased cytokine response in the absence of the capsule was not exclusive to type I IFN signaling. Several cytokines, including the proinflammatory IL-6, were increased in cells stimulated with the capsule-deficient strain, also observed in vivo. After 4 h in our acute pneumonia model, the burden of a capsule-null strain was significantly reduced, yet we observed increases in innate immune cells and inflammatory markers compared to wild-type A. baumannii. This study underscores the role of phase variation in the modulation of host immune responses and indicates that the capsule of A. baumannii plays an important role in protection against host cell killing and evasion from activation of the innate immune response.
登录
查看更多内容
影响因子：
15.9
作者：
Peignier A;Parker D
通讯作者：
Parker D
响应金黄色葡萄球菌肺部感染的IL-1β活化需要炎症体依赖和独立的机制。
影响因子：
5.4
作者：
Pires S;Parker D
通讯作者：
Parker D
影响因子：
6.7
作者：
Parker D;Planet PJ;Soong G;Narechania A;Prince A
通讯作者：
Prince A
DOI：
10.1084/jem.20031237
发表时间：
2004-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Doyle SE;O'Connell RM;Miranda GA;Vaidya SA;Chow EK;Liu PT;Suzuki S;Suzuki N;Modlin RL;Yeh WC;Lane TF;Cheng G
通讯作者：
Cheng G
I 型干扰素在多重耐药鲍曼不动杆菌感染过程中引起细胞焦亡和坏死性凋亡。
影响因子：
12.4
作者：
Li, Yang;Guo, Xiaomin;Qi, Xiaopeng
通讯作者：
Qi, Xiaopeng