Multiphysics Modeling of Plasmonic Photothermal Heating Effects in Gold Nanoparticles and Nanoparticle Arrays.
Multiphysics Modeling of Plasmonic Photothermal Heating Effects in Gold Nanoparticles and Nanoparticle Arrays.
复制标题
DOI：
10.1021/acs.jpcc.0c02443
复制
发表时间：
2020-08-06
期刊：
影响因子：
--
通讯作者：
Mayer KM
中科院分区：
文献类型：
--
作者：
Manrique-Bedoya S;Abdul-Moqueet M;Lopez P;Gray T;Disiena M;Locker A;Kwee S;Tang L;Hood RL;Feng Y;Large N;Mayer KM
由于大多数恶性组织的耐热性降低，诱导热疗已被证明是一种有效的肿瘤治疗方法;然而，大多数用于在靶体积内产生热量的技术选择性不足，诱导加热和对周围健康组织的意外损伤。等离子体光热疗法（PPTT）利用近红外（NIR）区域中的光在金纳米颗粒中诱导高度局部化的加热，充当外源性发色团，同时最小化附近组织中的热生成。然而，治疗参数的优化需要对每种新型的病理和治疗靶向组织进行广泛的体外和体内研究，这一过程可以通过实施计算建模而大大减少。在这里，我们描述了一个创新的模型的基础上的有限元法（FEM），结合光热加热物理在纳米尺度与微米尺度预测单个和阵列的金纳米粒子的热生成的发展。从激光照射等离子体激元加热计算金纳米粒子与三种不同的形态：nanobipyraxides，纳米棒，和纳米球。通过实验验证了基于可见波长（655 nm）的纳米棒的激光照射的模型预测，实验证明当由150 mW红色激光照射时，纳米棒阵列的粘度的温度增加5 °C。我们还提出了在810 nm处诱导的加热效应的预测模型，其中比较了共享该激发峰的各种形态的加热效率。我们的模型表明，在孤立的情况下，纳米棒是最有效的发热体，91 nm长的纳米棒阵列在超过20 μm3的体积内达到了过热水平（至少增加5 °C）。
Induced hyperthermia has been demonstrated as an effective oncological treatment due to the reduced heat tolerance of most malignant tissues; however, most techniques for heat generation within a target volume are insufficiently selective, inducing heating and unintended damage to surrounding healthy tissues. Plasmonic photothermal therapy (PPTT) utilizes light in the near-infrared (NIR) region to induce highly localized heating in gold nanoparticles, acting as exogenous chromophores, while minimizing heat generation in nearby tissues. However, optimization of treatment parameters requires extensive in vitro and in vivo studies for each new type of pathology and tissue targeted for treatment, a process that can be substantially reduced by implementing computational modeling. Herein, we describe the development of an innovative model based on the finite element method (FEM) that unites photothermal heating physics at the nanoscale with the micron scale to predict the heat generation of both single and arrays of gold nanoparticles. Plasmonic heating from laser illumination is computed for gold nanoparticles with three different morphologies: nanobipyramids, nanorods, and nanospheres. Model predictions based on laser illumination of nanorods at a visible wavelength (655 nm) are validated through experiments, which demonstrate a temperature increase of 5 °C in the viscinity of the nanorod array when illuminated by a 150 mW red laser. We also present a predictive model of the heating effect induced at 810 nm, wherein the heating efficiencies of the various morphologies sharing this excitation peak are compared. Our model shows that the nanorod is the most effective at heat generation in the isolated scenario, and arrays of 91 nm long nanorods reached hyperthermic levels (an increase of at least 5 °C) within a volume of over 20 μm3.
登录
查看更多内容
DOI：
10.3109/02656736.2013.864424
发表时间：
2014-02
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
MacLellan CJ;Fuentes D;Elliott AM;Schwartz J;Hazle JD;Stafford RJ
通讯作者：
Stafford RJ
影响因子：
3.8
作者：
Carpin, Laura B.;Bickford, Lissett R.;Drezek, Rebekah A.
通讯作者：
Drezek, Rebekah A.
影响因子：
2.4
作者：
Hood, R. Lyle;Andriani, Rudy T., Jr.;Rossmeisl, John H., Jr.
通讯作者：
Rossmeisl, John H., Jr.
影响因子：
17.1
作者：
Baffou, Guillaume;Quidant, Romain;Javier Garcia de Abajo, F.
通讯作者：
Javier Garcia de Abajo, F.
DOI：
10.1038/sc.1988.15
发表时间：
1988-04-01
期刊：
PARAPLEGIA
影响因子：
--
作者：
HUGHES, JT
通讯作者：
HUGHES, JT