Estimating nanoparticle optical absorption with magnetic resonance temperature imaging and bioheat transfer simulation.
Estimating nanoparticle optical absorption with magnetic resonance temperature imaging and bioheat transfer simulation.
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DOI：
10.3109/02656736.2013.864424
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Stafford RJ
中科院分区：
文献类型：
--
作者：
MacLellan CJ;Fuentes D;Elliott AM;Schwartz J;Hazle JD;Stafford RJ
用于热治疗应用的光激活纳米颗粒介导的加热是一个激烈的研究领域。表征这些粒子的时空加热潜力以用于在各种暴露条件下建模的能力可以帮助探索新的治疗方法以及更定量的前瞻性治疗计划方法。本研究的目的是调查热方程的逆解，使用磁共振温度成像（MRTI）反馈，提供两种类型的纳米粒子（金-二氧化硅纳米壳和金纳米棒）的光学表征。在暴露于808 nm激光期间，使用实时MRTI测量均匀纳米颗粒-琼脂混合物的光吸收。热传递的耦合有限元解与数据注册，并用于解决反问题。通过改变混合物的吸收系数，使用模式搜索算法使模型中的温度增加与MRTI之间的差异的L2范数最小化。吸收分数在类似纳米颗粒的文献值的10%以内。时间和空间配置文件的比较表明，模型和MRTI之间的定性协议。加权均方根误差<1.5 σMRTI，ΔT = 5°C等温线的平均Dice相似系数在测量的时间间隔内> 0.9。这项研究证明了使用间接方法对纳米颗粒吸收进行微创估计的可行性，该方法可以扩展到分析各种几何形状和感兴趣的颗粒。
Optically activated nanoparticle-mediated heating for thermal therapy applications is an area of intense research. The ability to characterize the spatiotemporal heating potential of these particles for use in modeling under various exposure conditions can aid in the exploration of new approaches for therapy as well as more quantitative prospective approaches to treatment planning. The purpose of this research was to investigate an inverse solution to the heat equation, using magnetic resonance temperature imaging (MRTI) feedback, for providing optical characterization of two types of nanoparticles (gold-silica nanoshells and gold nanorods). The optical absorption of homogeneous nanoparticle-agar mixtures was measured during exposure to an 808nm laser using real-time MRTI. A coupled finite element solution of heat transfer was registered with the data and used to solve the inverse problem. The L2 norm of the difference between the temperature increase in the model and MRTI was minimized using a pattern search algorithm by varying the absorption coefficient of the mixture. Absorption fractions were within 10% of literature values for similar nanoparticles. Comparison of temporal and spatial profiles demonstrated good qualitative agreement between the model and the MRTI. The weighted root mean square error was <1.5 σMRTI and the average Dice similarity coefficient for ΔT = 5°C isotherms was > 0.9 over the measured time interval. This research demonstrates the feasibility of using an indirect method for making minimally invasive estimates of nanoparticle absorption that might be expanded to analyze a variety of geometries and particles of interest.
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影响因子：
5.7
作者：
Eggebrecht, Adam T.;White, Brian R.;Ferradal, Silvina L.;Chen, Chunxiao;Zhan, Yuxuan;Snyder, Abraham Z.;Dehghani, Hamid;Culver, Joseph P.
通讯作者：
Culver, Joseph P.
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
DOI：
10.1016/0360-3016(85)90343-8
发表时间：
1985-01-01
影响因子：
7
作者：
ROEMER, RB;FLETCHER, AM;CETAS, TC
通讯作者：
CETAS, TC
影响因子：
3.7
作者：
Cole, Joseph R.;Mirin, Nikolay A.;Halas, Naomi J.
通讯作者：
Halas, Naomi J.
影响因子：
3.8
作者：
Seo, InSeok;Hayakawa, Carole K.;Venugopalan, Vasan
通讯作者：
Venugopalan, Vasan