Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency.
Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency.
复制标题
DOI：
10.1016/j.jaut.2012.01.015
复制
发表时间：
2012-06
影响因子：
12.8
通讯作者：
Bondy CA
中科院分区：
文献类型：
--
作者：
Bakalov VK;Gutin L;Cheng CM;Zhou J;Sheth P;Shah K;Arepalli S;Vanderhoof V;Nelson LM;Bondy CA
与男性相比，女性自身免疫性疾病的患病率较高可能是由于卵巢激素、妊娠和/或存在第二条X染色体的影响。为了阐明这些因素的作用，我们在美国国立卫生研究院进行了一项前瞻性研究，调查了与X染色体单体相关的原发性卵巢功能不全女性（特纳综合征，TS, n=244）和核型正常女性（46，XX）原发性卵巢功能不全（POI, n=457）的自身免疫诊断的患病率和谱。我们将研究组的患病率与美国女性人口的规范数据进行了比较。慢性淋巴细胞性（桥本氏）甲状腺炎（HT）发生在37%的TS女性和15%的POI女性中（P<0.0001）；两个卵巢功能不全组的HT患病率均显著高于美国女性人群（5.8%）。炎症性肠（IBD, 4%）和乳糜泻（CD, 2.7%）在TS中显著增加，但在POI中没有。其他自身免疫诊断，包括格雷夫斯病或1型糖尿病，在两组中均未出现显著增加。与POI和正常志愿者相比，TS患者的促炎il - 6和TGF - β1水平较高（p<0.0001），抗炎il - 10和TGF - β2水平较低（p<0.005）。与POI相比，TS的终生雌激素暴露和胎次显著低于POI，而POI又低于一般妇女群体。淋巴细胞性甲状腺炎在患有TS和POI的女性中都大大增加，这一发现表明与卵巢功能不全相关的因素本身促进了这种形式的自身免疫。缺乏正常的第二x染色体进一步增加了TS的自身免疫。
The higher prevalence of autoimmune diseases in women compared to men could be due to effects of ovarian hormones, pregnancy and/or the presence of a 2nd X chromosome. To elucidate the role of these factors, we investigated the prevalence and spectrum of autoimmune diagnoses in women with primary ovarian insufficiency associated with X chromosome monosomy (Turner syndrome, TS, n=244) and women with karyotypically normal (46,XX) primary ovarian insufficiency (POI, n=457) in a prospective study, conducted at the National Institutes of Health. We compared the study group prevalence to normative data for the U.S. population of women. Chronic lymphocytic (Hashimoto’s) thyroiditis (HT) occurred in 37% of women with TS vs. 15% with POI (P<0.0001); HT prevalence in both ovarian insufficiency groups significantly exceeded that in U.S. population of women (5.8%). Inflammatory bowel (IBD, 4%) and celiac disease (CD, 2.7%) were significantly increased in TS, but not in POI. No other autoimmune diagnosis, including Graves’ disease or Type 1 diabetes appears to be significantly increased in either group. Women with TS had higher pro-inflammatory IL6 and TGF β1 levels (p<0.0001 for both), and lower anti-inflammatory IL10 and TGF β2 levels (p<0.005 for both) compared to POI and to normal volunteers. Lifetime estrogen exposure and parity were significantly lower in TS compared to POI, which were in turn lower than the general population of women. The finding that lymphocytic thyroiditis is greatly increased in both women with TS and POI suggests that factors associated with ovarian insufficiency per se promote this form of autoimmunity. The absence of a normal second X-chromosome further contributes to increased autoimmunity in TS.
登录
查看更多内容
影响因子：
5.8
作者：
Bakalov, Vladimir K.;Cheng, Clara;Bondy, Carolyn A.
通讯作者：
Bondy, Carolyn A.
影响因子：
--
作者：
Jorgensen, Kristian T.;Rostgaard, Klaus;Frisch, Morten
通讯作者：
Frisch, Morten
DOI：
10.1097/01.gme.0000248702.25259.00
发表时间：
2006-11-01
影响因子：
2.7
作者：
Corrigan, Emily C.;Nelson, Lawrence M.;Bondy, Carolyn A.
通讯作者：
Bondy, Carolyn A.
影响因子：
7.2
作者：
Gravholt, CH;Juul, S;Hansen, J
通讯作者：
Hansen, J
影响因子：
3.2
作者：
Elsheikh, M;Wass, JAH;Conway, GS
通讯作者：
Conway, GS