The P2X1 ion channel in platelet function
The P2X1 ion channel in platelet function
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P2X1离子通道在血小板功能中的作用
DOI：
10.3109/09537101003599549
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发表时间：
2010
期刊：
影响因子：
3.3
通讯作者：
M. Hoylaerts
中科院分区：
文献类型：
--
作者：
Hu Hu;M. Hoylaerts
在血管损伤后，腺苷酸ATP从粘附和活化的血小板的致密颗粒以及从受损的内皮细胞和受损的红细胞释放。ATP通过自分泌和旁分泌机制与血小板膜中的离子通道P2X1瞬间相互作用，放大血小板活化事件的初始阶段。大量的体外和体内血小板活化研究已经将P2X1鉴定为具有独特药理学特征的受体，能够调节各种细胞内信号级联，涉及血小板功能。本文综述了血小板P2X1受体及其下游信号通路的功能，在过去的二十年中收集的结果，对最近在体内观察血栓形成模型中P2X1基因缺陷和转基因小鼠。我们目前对其生理学的理解已经确定血小板P2X1作为血栓形成管理的靶点，其抑制可能能够调节血小板功能。鉴于特异性激动剂和拮抗剂的可用性，P2X1也被讨论作为抗血栓治疗的治疗靶点。
Following vascular injury, the adenosine nucleotide ATP is released from the dense granules of adhering and activated platelets, as well as from injured endothelial cells and damaged red blood cells. ATP instantaneously interacts with the ion channel P2X1 in the platelet membrane, through autocrine and paracrine mechanisms, amplifying the initial phase of a platelet activation event. A multitude of platelet activation studies in vitro and in vivo have identified P2X1 as a receptor with a distinct pharmacological profile, capable of regulating various intracellular signaling cascades, implicated in platelet function. This review discusses findings on the function of the platelet P2X1 receptor and its downstream signaling pathways, collected over the last two decades, against more recent in vivo observations in thrombosis models in P2X1 gene-deficient and transgenic mice. Our present understanding of its physiology has identified platelet P2X1 as a target in the management of thrombosis, its inhibition potentially capable of platelet function modulation. In view of the availability of specific agonists and antagonists, P2X1 is also discussed as a therapeutic target for antithrombotic therapy.
影响因子：
7.3
作者：
Kim, YC;Brown, SG;Jacobson, KA
通讯作者：
Jacobson, KA
小鼠肾脏中 NTPDase1 和 NTPDase2 的表达：与 P2 受体信号传导调节的相关性。
DOI：
10.1152/ajprenal.00108.2004
发表时间：
2005
期刊：
American journal of physiology. Renal physiology
影响因子：
--
作者：
Kishore,BellamkondaK;Isaac,Jorge;Fausther,Michel;Tripp,SherylR;Shi,Huihui;Gill,PritmohinderS;Braun,Norbert;Zimmermann,Herbert;Sévigny,Jean;Robson,SimonC
通讯作者：
Robson,SimonC