KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway
KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway
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KIAA1199 通过激活 IL-6/STAT3 通路诱导卵巢癌的高级生物学行为和发展
DOI：
10.32604/biocell.2022.016225
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发表时间：
2022
期刊：
影响因子：
1.2
通讯作者：
Yunzhao Xu
中科院分区：
文献类型：
--
作者：
Shuting Gu;Jingyi Qin;Sainan Gao;Zhen Wang;Qi Meng;Yan Li;Bing Lu;Songlin Zhou;Yunzhao Xu
近期，在上皮性卵巢癌（EOC）中检测到KIAA1199异常表达。然而，KIAA1199潜在的抗卵巢癌机制仍有待阐明。在我们的研究中，我们着手阐明KIAA1199对……的影响
Recently, abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer (EOC). However, the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be enlightened. In our study, we performed to elucidate the effects of KIAA1199 on the advanced biological behavior of EOC cells through activation of the IL-6/STAT3 pathway. Confirmed by immunohistochemistry, KIAA1199 was highly expressed in ovarian borderline and malignant epithelial tumors. A retrospective analysis found that EOC patients with low expression of KIAA1199 had a significantly higher 5-year survival rate than those with high expression. Mechanistically, IL-6 was used to stimulate EOC cells, and the expression of KIAA1199, STAT3 and p-STAT3 increased after IL-6 stimulation. These results could show that KIAA1199 is transcriptionally activated by IL6/STAT3 pathway, thereby accelerating the deterioration of EOC. KIAA1199 could also be used as a poor prognosis factor and potential target in treatment.
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影响因子：
5.7
作者：
Kitamura H;Ohno Y;Toyoshima Y;Ohtake J;Homma S;Kawamura H;Takahashi N;Taketomi A
通讯作者：
Taketomi A
DOI：
10.1007/978-1-59259-768-0_35
发表时间：
2018-06
期刊：
An Atlas of Gynecologic Oncology
影响因子：
--
作者：
Kristin K. Zorn;Ginger J. Gardner;Michael J. Birrer
通讯作者：
Kristin K. Zorn;Ginger J. Gardner;Michael J. Birrer
影响因子：
6.2
作者：
Lee, Jung-Min;Minasian, Lori;Kohn, Elise C.
通讯作者：
Kohn, Elise C.
DOI：
10.18632/aging.103964
发表时间：
2020-11-10
期刊：
Aging
影响因子：
--
作者：
Zhai X;Wang W;Ma Y;Zeng Y;Dou D;Fan H;Song J;Yu X;Xin D;Du G;Jiang Z;Zhang H;Zhang X;Jin B
通讯作者：
Jin B
KIAA1199 的敲低可减弱肝细胞癌的生长和转移。
影响因子：
7
作者：
Liu J;Han P;Gong J;Wang Y;Chen B;Liao J;Tian D
通讯作者：
Tian D