Branching Off: New Insight Into Lysosomes as Tubular Organelles.
Branching Off: New Insight Into Lysosomes as Tubular Organelles.
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分支：作为管状细胞器的溶酶体的新见解。
DOI：
10.3389/fcell.2022.863922
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
溶酶体是一种酸性的膜结合细胞器，在细胞质量控制、代谢和信号传导中起着重要作用。细胞的溶酶体通常被描述为囊状细胞器。然而，溶酶体实际上表现出高度的超微结构异质性。在某些生物学环境下，溶酶体膜自然地转变为管状，非泡状形态。尽管对管状溶酶体的目的和调控一直研究不足，但新出现的证据表明，管状溶酶体可能具有独特的降解和非降解活性，这些活性对细胞行为、功能和活力至关重要。在这里，我们讨论了在理解管状溶酶体在细胞生理学中的生物学意义方面的最新进展，我们强调了越来越多的例子，表明这类特殊的溶酶体对健康和疾病的中心作用。
Lysosomes are acidic, membrane-bound organelles that play essential roles in cellular quality control, metabolism, and signaling. The lysosomes of a cell are commonly depicted as vesicular organelles. Yet, lysosomes in fact show a high degree of ultrastructural heterogeneity. In some biological contexts, lysosome membranes naturally transform into tubular, non-vesicular morphologies. Though the purpose and regulation of tubular lysosomes has been historically understudied, emerging evidence suggests that tubular lysosomes may carry out unique activities, both degradative and non-degradative, that are critical to cell behavior, function, and viability. Here, we discuss recent advances in understanding the biological significance of tubular lysosomes in cellular physiology, and we highlight a growing number of examples that indicate the centrality of this special class of lysosomes to health and disease.
植物肉芽菌醋酸盐刺激小鼠巨噬细胞中的微管和10 nm细丝延伸和溶酶体重新分布。
影响因子：
7.8
作者：
Phaire-Washington, L;Silverstein, S C;Wang, E
通讯作者：
Wang, E