Clinical characteristics and respiratory support of 310 COVID-19 patients, diagnosed at the emergency room: a single-center retrospective study.
Clinical characteristics and respiratory support of 310 COVID-19 patients, diagnosed at the emergency room: a single-center retrospective study.
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在急诊室被诊断出的310名Covid-19患者的临床特征和呼吸支持：一项单中心回顾性研究。
DOI：
10.1007/s11739-020-02548-0
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发表时间：
2021-06
影响因子：
4.6
通讯作者：
Strozzi MA
中科院分区：
文献类型：
--
作者：
Di Domenico SL;Coen D;Bergamaschi M;Albertini V;Ghezzi L;Cazzaniga MM;Tombini V;Colombo R;Capsoni N;Coen T;Cazzola KB;Di Fiore M;Angaroni L;Strozzi MA
2020 年 2 月底，意大利伦巴第大区持续爆发与严重急性呼吸道冠状病毒 2 (SARS-CoV-2) 相关的肺炎。我们分析了一项回顾性、单中心病例系列的数据，其中包括 310 名连续入院急诊室确诊 SARS-CoV-2 感染的患者。我们的目的是描述一组 COVID-19 肺炎患者的临床病程、治疗和结果，特别关注氧气输送和呼吸机支持。在整个研究期间，连续 310 名确诊 SARS-CoV-2 感染的患者前往急诊室 (ER) 就诊，其中 34 人直接从急诊室出院回家。其余 276 名患者中，总死亡率为 30.4%：7 名患者在急诊室死亡，77 名患者在住院期间死亡。关于氧气输送：22 名患者不需要任何氧气支持（8.0%），151 名患者仅接受氧气治疗（54.7%），49 名患者（17.8%）进行插管。 90 名患者（32.6%）接受了 CPAP（持续气道正压通气）或 NIV（无创通气）治疗；在该组中，27 名患者接受了不插管 (DNI) 指令，并接受 CPAP/NIV 作为上限治疗，死亡率很高 (88.9%)。在未进行DNI的情况下接受CPAP/NIV治疗的63例患者中，有36例患者（57.1%）发生NIV失败，死亡率为47.2%。二十七 (27) 名患者接受了 CPAP/NIV 治疗，无需机械通气，其中 26 名患者存活出院 (96.3%)。该研究记录了严重呼吸衰竭患者的预后不良，尽管相当少数接受 CPAP/NIV 治疗的患者取得了积极的结果。
An ongoing outbreak of pneumonia associated with severe acute respiratory coronavirus 2 (SARS-CoV-2) occurred at the end of February 2020 in Lombardy, Italy. We analyzed data from a retrospective, single-center case series of 310 consecutive patients, with confirmed SARS-CoV-2 infection, admitted to the emergency room. We aimed to describe the clinical course, treatment and outcome of a cohort of patients with COVID-19 pneumonia, with special attention to oxygen delivery and ventilator support. Throughout the study period, 310 consecutive patients, with confirmed SARS-CoV-2 infection, attended the Emergency Room (ER), of these, 34 were discharged home directly from the ER. Of the remaining 276 patients, the overall mortality was 30.4%: 7 patients died in the ER and 77 during hospitalization. With respect to oxygen delivery: 22 patients did not need any oxygen support (8.0%), 151 patients were treated with oxygen only (54.7%), and 49 (17.8%) were intubated. 90 patients (32.6%) were treated with CPAP (Continuous Positive Airway Pressure) or NIV (Non Invasive Ventilation); in this group, 27 patients had a Do Not Intubate (DNI) order and were treated with CPAP/NIV as an upper threshold therapy, showing high mortality rate (88.9%). Among the 63 patients treated with CPAP/NIV without DNI, NIV failure occurred in 36 patients (57.1%), with mortality rate of 47.2%. Twenty-seven (27) patients were treated with CPAP/NIV without needing mechanical ventilation and 26 were discharged alive (96.3%). The study documents the poor prognosis of patients with severe respiratory failure, although a considerable minority of patients treated with CPAP/NIV had a positive outcome.
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影响因子：
11.8
作者：
Gnavi, Roberto;Demaria, Moreno;Costa, Giuseppe
通讯作者：
Costa, Giuseppe
影响因子：
158.5
作者：
Cavalcanti, A. B.;Zampieri, F. G.;Berwanger, O.
通讯作者：
Berwanger, O.
影响因子：
7.7
作者：
Wang, Ying;Chaffee, Thomas S.;Schwertfeger, Kathryn L.
通讯作者：
Schwertfeger, Kathryn L.
DOI：
10.1111/j.1469-0691.2012.03797.x
发表时间：
2013-03
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Masclans JR;Pérez M;Almirall J;Lorente L;Marqués A;Socias L;Vidaur L;Rello J;H1N1 GTEI/SEMICYUC Investigators
通讯作者：
H1N1 GTEI/SEMICYUC Investigators
DOI：
10.1016/j.ijantimicag.2020.105949
发表时间：
2020-07-01
影响因子：
10.8
作者：
Gautret, Philippe;Lagier, Jean-Christophe;Raoult, Didier
通讯作者：
Raoult, Didier