Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy.
Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy.
复制标题
DOI：
10.3390/life12040542
复制
发表时间：
2022-04-06
期刊：
影响因子：
3.2
通讯作者：
Kurihara, Toshihide
中科院分区：
文献类型：
--
作者：
Ofuji, Yoshiko;Katada, Yusaku;Tomita, Yohei;Nagai, Norihiro;Sonobe, Hideki;Watanabe, Kazuhiro;Shinoda, Hajime;Ozawa, Yoko;Negishi, Kazuno;Tsubota, Kazuo;Kurihara, Toshihide
眼底荧光血管造影是日本的一项标准检查，可以直接观察糖尿病视网膜病变的循环衰竭情况，但在西方国家并未使用。在本研究中，我们研究了眼底荧光血管造影中的非灌注区域与糖尿病视网膜病变进展之间的关系。我们评估了 22 名患者的 22 只眼睛，这些患者于 2012 年 1 月至 2015 年 5 月在庆应义塾大学医院的一次临床发作期间进行了首次眼底荧光血管造影，被诊断为患有增殖前糖尿病视网膜病变，并且可以随访至少三年。计算初次眼底荧光血管造影中九段眼底的无灌注面积指数（%），并评估三年内向增殖性糖尿病视网膜病变的进展情况。 22 只眼睛中的 3 只（13.6%）在三年内出现了增殖性糖尿病视网膜病变。初始眼底荧光血管造影的非灌注面积指数与增殖性糖尿病视网膜病变的进展显着相关。后极部的非灌注面积指数与增殖性糖尿病视网膜病变的进展密切相关。因此，患有增殖前糖尿病视网膜病变的患者后极部的非灌注面积指数可以预测随后三年内进展为增殖性糖尿病视网膜病变的情况。
Fundus fluorescent angiography is a standard examination in Japan that can directly visualize the circulatory failure in diabetic retinopathy but is not used in Western countries. In this study, we examine the relationship between the non-perfusion area in fundus fluorescent angiography and the progression of diabetic retinopathy. We evaluated 22 eyes between 22 patients who had their first fundus fluorescent angiography during a clinical episode at Keio University Hospital from January 2012 to May 2015, were diagnosed as having preproliferative diabetic retinopathy, and could be followed for at least three years. The non-perfusion area index (%) in nine segmented fundi in the initial fundus fluorescent angiography was calculated, and the progression to proliferative diabetic retinopathy over three years was evaluated. Three out of the 22 eyes (13.6%) developed proliferative diabetic retinopathy over three years. The non-perfusion area index for the initial fundus fluorescent angiography was significantly associated with progression to proliferative diabetic retinopathy. The non-perfusion area index in the posterior pole was most strongly correlated with the progression to proliferative diabetic retinopathy. Thus, the non-perfusion area index in the posterior pole among those with preproliferative diabetic retinopathy may predict the progression to proliferative diabetic retinopathy in the subsequent three years.
登录
查看更多内容
影响因子：
13.7
作者：
Olsen, Timothy W.;Al-Rajhi, Ali;Lum, Flora C.
通讯作者：
Lum, Flora C.
影响因子：
16.2
作者：
Solomon SD;Chew E;Duh EJ;Sobrin L;Sun JK;VanderBeek BL;Wykoff CC;Gardner TW
通讯作者：
Gardner TW
影响因子：
13.7
作者：
Silva, Paolo S.;Dela Cruz, Amanda J.;Aiello, Lloyd Paul
通讯作者：
Aiello, Lloyd Paul
影响因子：
8.2
作者：
Kawasaki, R.;Tanaka, S.;Yamashita, H.
通讯作者：
Yamashita, H.
影响因子：
4.2
作者：
Fan, Wenying;Wang, Kang;Sadda, Srinivas R.
通讯作者：
Sadda, Srinivas R.