Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.
Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.
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DOI：
10.1111/j.1474-9726.2011.00772.x
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发表时间：
2012-04
期刊：
影响因子：
7.8
通讯作者：
Buffenstein R
中科院分区：
文献类型：
--
作者：
Edrey YH;Casper D;Huchon D;Mele J;Gelfond JA;Kristan DM;Nevo E;Buffenstein R
裸鼹鼠（Heterocephalus glaber）是最长寿的啮齿类动物，其寿命是同等大小小鼠的7-10倍，其一生中约75%的时间都能正常活动。人们对它们延缓衰老和长寿的机制知之甚少。神经调节蛋白-1 （NRG-1）信号在发育和成年期间对正常的大脑功能至关重要。我们假设长寿的物种将维持较高水平的NRG-1，这有助于它们维持大脑功能和伴随的正常活动维持。我们监测了不同年龄（1天至26岁）黄貂的NRG-1及其受体ErbB4的水平，发现NRG-1和ErbB4的水平在整个发育和成年期都保持不变。此外，我们比较了7种最大寿命潜力（MLSP）差异较大（4-32岁）的啮齿动物，发现在生理等效年龄，寿命较长的啮齿动物具有较高的NRG-1和ErbB4水平。此外，系统发育独立的对比分析显示，MLSP和NRG-1水平之间的这种显著的强相关性与系统发育无关。这些结果表明，NRG-1通过其维持神经元完整性的作用，是促成不同物种MLSP的重要因素。
Naked mole-rats (Heterocephalus glaber), the longest-lived rodents, live 7-10 times longer than similarly–sized mice and exhibit normal activities for ~75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is critical for normal brain function during both development and adulthood. We hypothesized that long-lived species will maintain higher levels of NRG-1 and that this contributes to their sustained brain function and concomitant maintenance of normal activity. We monitored the levels of NRG-1 and its receptor ErbB4 in H. glaber at different ages ranging from 1 day to 26 years and found that levels for NRG-1 and ErbB4 were sustained throughout development and adulthood. In addition, we compared seven rodent species with widely divergent (4-32y) maximum lifespan potential (MLSP) and found that at a physiologically-equivalent age, the longer-lived rodents had higher levels of NRG-1 and ErbB4. Moreover, phylogenetic independent contrast analyses revealed that this significant strong correlation between MLSP and NRG-1 levels was independent of phylogeny. These results suggest that NRG-1 is an important factor contributing to divergent species MLSP through its role in maintaining neuronal integrity.
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影响因子：
3.8
作者：
Buonanno A
通讯作者：
Buonanno A
DOI：
10.1016/0300-9629(79)90197-x
发表时间：
1979-01-01
影响因子：
2.3
作者：
ARIELI, R
通讯作者：
ARIELI, R
DOI：
10.1073/pnas.0701289104
发表时间：
2007-05-01
影响因子：
11.1
作者：
Huchon, Dorothee;Chevret, Pascale;Schmitz, Juergen
通讯作者：
Schmitz, Juergen
影响因子：
7.8
作者：
Andziak, Blazej;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle
影响因子：
3.9
作者：
Edrey, Yael H.;Park, Thomas J.;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle