Functionalized organic nanotubes with highly tunable crosslinking site density for mechanical enhancement and pH-controlled drug release of nanocomposite hydrogels
Functionalized organic nanotubes with highly tunable crosslinking site density for mechanical enhancement and pH-controlled drug release of nanocomposite hydrogels
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具有高度可调交联位点密度的功能化有机纳米管，用于纳米复合水凝胶的机械增强和 pH 控制药物释放
DOI：
10.1038/s41428-021-00556-1
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发表时间：
2021
期刊：
影响因子：
2.8
通讯作者：
Kameta Naohiro
中科院分区：
文献类型：
--
作者：
Wu Dongwei;Ding Wuxiao;Kameta Naohiro
有机纳米管由于其独特的内、外纳米空间结构在生物医学领域的应用越来越受到人们的关注。在这里，ONT的功能化和杂化与聚（乙二醇）（PEG）构建纳米复合水凝胶，其目的是提高其机械强度和控制其释放性能。这些纳米工程水凝胶具有比未增强的水凝胶大4倍的机械刚度，并且显示出更稳定的网络。系统地评估了ONT浓度和交联位点密度对水凝胶力学性能的影响。此外，ONT的掺入使得模型药物能够简单有效地后加载，以及从水凝胶的持续药物释放曲线。这些结果提供了一种新的方法来产生机械增强的纳米复合水凝胶与改善药物输送在一个简单的，有效的和可调的方式，所获得的纳米复合水凝胶可能有潜在的应用在药物输送和其他相关的生物应用。
Organic nanotubes (ONTs) have attracted growing attention in biomedical applications because of their unique inner and outer nanospaces. Here, ONTs were functionalized and hybridized with poly(ethylene glycol) (PEG) to construct nanocomposite hydrogels, with the aim of enhancing their mechanical strength and controlling their release properties. These nanoengineered hydrogels have 4-fold greater mechanical stiffness than unreinforced hydrogels and show a more stable network. The effects of ONT concentration and crosslinkable site density on the hydrogel mechanical properties were systematically assessed. Moreover, the incorporation of ONTs enabled simple and effective post-loading of the model drug, as well as a sustained drug release profile from the hydrogels. These results provide a novel method to generate mechanically enhanced nanocomposite hydrogels with improved drug delivery in an easy, efficient and tunable manner, and the obtained nanocomposite hydrogels may have potential applications in drug delivery and other related bioapplications.
影响因子：
6.6
作者：
Gaharwar AK;Patel A;Dolatshahi-Pirouz A;Zhang H;Rangarajan K;Iviglia G;Shin SR;Hussain MA;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
8
作者：
Ding W;Minamikawa H;Kameta N;Shimizu T;Masuda M
通讯作者：
Masuda M