Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis.
Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis.
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DOI：
10.1038/s41598-021-85359-3
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发表时间：
2021-03-18
影响因子：
4.6
通讯作者：
Du P
中科院分区：
文献类型：
--
作者：
Ssentongo P;Heilbrunn ES;Ssentongo AE;Advani S;Chinchilli VM;Nunez JJ;Du P
人类免疫缺陷病毒 (HIV)/获得性免疫缺陷综合征 (AIDS) (PLWHA) 感染者对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的易感性和死亡风险在很大程度上尚不清楚。 PLWHA 的独特之处在于，他们的免疫系统因慢性 HIV 感染史而改变，并且使用抗逆转录病毒疗法，其中一些疗法已被实验性地用于治疗 2019 年冠状病毒病 (COVID-19)。因此，我们进行了系统回顾和荟萃分析，以评估 SARS-COV-2/HIV 双重感染的流行病学并估计 COVID-19 的相关死亡率（Prospero 注册 ID：CRD42020187980）。检索时间为 2020 年 1 月 1 日至 2020 年 12 月 12 日。检索了 PubMed、SCOPUS、OVID 和 Cochrane 图书馆数据库以及 medRxiv 预印本存储库。数据来自报告 PLWHA 与 HIV 阴性人群相比的 COVID-19 发病率和死亡率的研究。使用随机效应模型对汇总发病和死亡风险进行量化。我们确定了 22 项研究，涉及北美、非洲、欧洲和亚洲的 20,982,498 名参与者。平均年龄为 56 岁，其中 50% 为男性。 HIV 阳性者感染 SARS-CoV-2 的风险[风险比 (RR) 1.24，95% CI 1.05–1.46)] 和 COVID-19 死亡率（RR 1.78，95% CI 1.21–2.60）显着高于 HIV 阴性者。替诺福韦和蛋白酶抑制剂在降低 PLWHA 中 SARS-CoV-2 感染和 COVID-19 死亡风险方面的有益作用仍无定论。 HIV 仍然是感染 SARS-CoV-2 的一个重要风险因素，并且与 COVID-19 的较高死亡风险相关。为了支持当前的疾病控制和预防中心 (CDC) 指南，艾滋病毒感染者需要优先考虑接种 SARS-CoV-2 疫苗。
Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk of mortality among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA) is largely unknown. PLWHA are unique due to their altered immune system from their history of chronic HIV infection and their use of antiretroviral therapy, some of which have been used experimentally to treat coronavirus disease 2019 (COVID-19). Therefore, we conducted a systematic review and meta-analysis to assess the epidemiology of SARS-COV-2/HIV coinfection and estimate associated mortality from COVID-19 (Prospero Registration ID: CRD42020187980). PubMed, SCOPUS, OVID and Cochrane Library databases, and medRxiv preprint repositories were searched from January 1, 2020, to December 12, 2020. Data were extracted from studies reporting COVID-19 attack and mortality rates in PLWHA compared to their HIV-negative counterparts. Pooled attack and mortality risks were quantified using random-effects models. We identified 22 studies that included 20,982,498 participants across North America, Africa, Europe, and Asia. The median age was 56 years, and 50% were male. HIV-positive persons had a significantly higher risk of SARS-CoV-2 infection [risk ratio (RR) 1.24, 95% CI 1.05–1.46)] and mortality from COVID-19 (RR 1.78, 95% CI 1.21–2.60) than HIV-negative individuals. The beneficial effects of tenofovir and protease-inhibitors in reducing the risk of SARS-CoV-2 infection and death from COVID-19 in PLWHA remain inconclusive. HIV remains a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality from COVID-19. In support of the current Centers for Disease Control and Prevention (CDC) guidelines, persons with HIV need priority consideration for the SARS-CoV-2 vaccine.
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DOI：
10.1093/cid/ciaa1605
发表时间：
2021-10-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Geretti AM;Stockdale AJ;Kelly SH;Cevik M;Collins S;Waters L;Villa G;Docherty A;Harrison EM;Turtle L;Openshaw PJM;Baillie JK;Sabin CA;Semple MG
通讯作者：
Semple MG
纽约市公立医院系统中Covid-19患者的特征和结果。
影响因子：
3.7
作者：
Kalyanaraman Marcello R;Dolle J;Grami S;Adule R;Li Z;Tatem K;Anyaogu C;Apfelroth S;Ayinla R;Boma N;Brady T;Cosme-Thormann BF;Costarella R;Ford K;Gaither K;Jacobson J;Kanter M;Kessler S;Kristal RB;Lieber JJ;Mukherjee V;Rizzo V Jr;Rowell M;Stevens D;Sydney E;Wallach A;Chokshi DA;Davis N;New York City Health + Hospitals COVID-19 Population Health Data Team
通讯作者：
New York City Health + Hospitals COVID-19 Population Health Data Team
影响因子：
39.2
作者：
del Amo, Julia;Polo, Rosa;Hernan, Miguel A.
通讯作者：
Hernan, Miguel A.
影响因子：
2.2
作者：
DerSimonian, Rebecca;Kacker, Raghu
通讯作者：
Kacker, Raghu
影响因子：
1.6
作者：
D'Souza, Gypsyamber;Springer, Gayle;Adimora, Ada A.
通讯作者：
Adimora, Ada A.