5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
复制标题
DOI：
10.1371/journal.pone.0031701
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Medeiros AI
中科院分区：
文献类型：
--
作者：
Secatto A;Rodrigues LC;Serezani CH;Ramos SG;Dias-Baruffi M;Faccioli LH;Medeiros AI
5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes during Histoplasma capsulatum infection in vivo and in vitro. 5-LO deficiency led to increased lung CFU, decreased nitric oxide production and a deficient primary immune response during active fungal infection. Moreover, H. capsulatum-infected 5-LO−/− mice showed an intense influx of neutrophils and an impaired ability to generate and recruit effector T cells to the lung. The fungal susceptibility of 5-LO−/− mice correlated with a lower rate of macrophage ingestion of IgG-H. capsulatum relative to WT macrophages. Conversely, exogenous LTB4 and LTC4 restored macrophage phagocytosis in 5-LO deficient mice. Our results demonstrate that leukotrienes are required to control chronic fungal infection by amplifying both the innate and adaptive immune response during histoplasmosis.
登录
查看更多内容
影响因子：
20.3
作者：
Canetti, C;Hu, B;Peters-Golden, M
通讯作者：
Peters-Golden, M
影响因子：
4.4
作者：
Medeiros, Alexandra I.;Sa-Nunes, Anderson;Faccioli, Lucia H.
通讯作者：
Faccioli, Lucia H.
影响因子：
15.9
作者：
NEWMAN, SL;GOOTEE, L;GABAY, JE
通讯作者：
GABAY, JE
影响因子：
3.1
作者：
Kobayashi, Yoshiro
通讯作者：
Kobayashi, Yoshiro
影响因子：
5.5
作者：
KURITA, N;TERAO, K;MIYAJI, M
通讯作者：
MIYAJI, M