Host Cell Receptors Implicated in the Cellular Tropism of BVDV.
Host Cell Receptors Implicated in the Cellular Tropism of BVDV.
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DOI：
10.3390/v14102302
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发表时间：
2022-10-20
期刊：
影响因子：
--
通讯作者：
Yin X
中科院分区：
文献类型：
--
作者：
Qi S;Wo L;Sun C;Zhang J;Pang Q;Yin X
牛病毒性腹泻病毒(BVDV)是危害最大的病毒之一，给世界养牛业造成巨大的经济损失。近年来，世界范围内鼠疫病毒的多样性不断增加。BVDV是黄病毒科疫病毒属的一员，宿主动物广泛，包括牛、山羊、绵羊、猪、骆驼等偶蹄动物，并具有多组织嗜性。病毒通过与细胞受体的相互作用识别它们的允许细胞是成功感染的先决条件。到目前为止，关于BVDV进入BVDV所必需的细胞受体及其在BVDV感染过程中的具体功能还知之甚少。因此，发现参与BVDV和其他鼠疫病毒进入的细胞受体对于开发新的干预措施具有重要意义。病毒包膜糖蛋白Erns和E2是BVDV细胞嗜性的关键决定因素。与Erns和E2结合的细胞蛋白可能参与了BVDV的进入，它们的丰度可能决定了BVDV的细胞趋向性。在这里，我们总结了目前关于BVDV进入的细胞分子的知识，如补体调节蛋白46(CD46)、硫酸肝素(HS)、低密度脂蛋白(LDL)受体以及去整合素和金属蛋白酶17(ADAM17)。此外，我们还重点讨论了最近发现的BVDV生命周期中的鼠疫病毒细胞受体的含义。这一认识为通过靶向BVDV感染所必需的细胞受体来防治BVDV提供了理论基础。
Bovine viral diarrhea virus (BVDV) is one of the most hazardous viruses, which causes huge economic losses in the cattle industry around the world. In recent years, there has been a continuous increase in the diversity of pestivirus worldwide. As a member of the genus Pestivirus in the Flaviviridae family, BVDV has a wide range of host animals including cattle, goat, sheep, pig, camel and other cloven-hoofed animals, and it has multi-tissue tropism as well. The recognition of their permissive cells by viruses via interaction with the cellular receptors is a prerequisite for successful infection. So far, little is known about the cellular receptors essential for BVDV entry and their detailed functions during BVDV infection. Thus, discovery of the cellular receptors involved in the entry of BVDV and other pestiviruses is significant for development of the novel intervention. The viral envelope glycoprotein Erns and E2 are crucial determinants of the cellular tropism of BVDV. The cellular proteins bound with Erns and E2 potentially participate in BVDV entry, and their abundance might determine the cellular tropism of BVDV. Here, we summarize current knowledge regarding the cellular molecules have been described for BVDV entry, such as, complement regulatory protein 46 (CD46), heparan sulfate (HS), the low-density lipoprotein (LDL) receptor, and a disintegrin and metalloproteinase 17 (ADAM17). Furthermore, we focus on their implications of the recently identified cellular receptors for pestiviruses in BVDV life cycle. This knowledge provides a theoretical basis for BVDV prevention and treatment by targeting the cellular receptors essential for BVDV infection.
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