SNPSTR: a database of compound microsatellite-SNP markers.

SNPSTR: a database of compound microsatellite-SNP markers.
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SNPSTR:复合微卫星-SNP标记的数据库。

DOI:
10.1093/nar/gkl806
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发表时间:
2007-01
影响因子:
14.9
通讯作者:
Stumpf MP
Stumpf MP
中科院分区:
生物学2区
文献类型:
--
作者:
Agrafioti I;Stumpf MP

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人们对遗传标记的兴趣越来越大,这些标记适合于对过去的人口统计学事件进行群体遗传推断,并检测选择的影响。除了单核苷酸多态性(SNPs),微卫星(或短串联重复序列,STR)在人类人口历史分析中也受到了极大的关注。在SNPSTR数据库()中,我们将一种相对较新的复合遗传标记称为SNPSTR,它将微卫星标记(STR)与一个或多个紧密连锁的SNP结合起来。这里,SNP和微卫星相距小于250 bp,因此每个SNPSTR可以被认为是两个个体标记之间不发生重组的小单倍型。因此,SNPSTR有可能成为群体遗传学领域非常有用的工具。SNPSTR数据库包含所有可推断的人类SNPSTR以及小鼠、大鼠、狗和鸡中的SNPSTR,即可获得广泛SNP数据集的所有模式生物。
There has been widespread and growing interest in genetic markers suitable for drawing population genetic inferences about past demographic events and to detect the effects of selection. In addition to single nucleotide polymorphisms (SNPs), microsatellites (or short tandem repeats, STRs) have received great attention in the analysis of human population history. In the SNPSTR database () we catalogue a relatively new type of compound genetic marker called SNPSTR which combines a microsatellite marker (STR) with one or more tightly linked SNPs. Here, the SNP(s) and the microsatellite are less than 250 bp apart so each SNPSTR can be considered a small haplotype with no recombination occurring between the two individual markers. Thus, SNPSTRs have the potential to become a very useful tool in the field of population genetics. The SNPSTR database contains all inferable human SNPSTRs as well as those in mouse, rat, dog and chicken, i.e. all model organisms for which extensive SNP datasets are available.
DOI: 10.1038/368455a0
发表时间: 1994-03-31
期刊: NATURE
影响因子: 64.8
作者:
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