Structural and Genetic Basis of the Major Cross-Reactive Idiotype of the A Strain Mouse
Structural and Genetic Basis of the Major Cross-Reactive Idiotype of the A Strain Mouse
复制标题
A品系小鼠主要交叉反应独特型的结构和遗传基础
DOI：
10.1007/978-1-4684-4739-2_3
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发表时间：
1984
影响因子：
4.4
通讯作者：
J. Capra
中科院分区：
文献类型：
--
作者：
C. Slaughter;J. Capra
Structural features peculiar to the variable regions of antibodies are widely believed to interact with regulatory forces which help to control and fine-tune the specific immune responses in which these antibodies participate.(1) The serologically recognized features of antibody variable regions known as idiotypes(2,3) constitute structurally definable analogs of the sites which interact with regulatory forces in this way, and they may in some cases be identical to such sites. Over the last decade, a number of laboratories have devoted considerable effort to the detailed chemical characterization of idiotypic determinants on antibody molecules. Most of this research has centered on structural comparisons of antibodies or myeloma proteins which belong to families of related molecules sharing a common specificity for antigen but differing in their expression of a cross-reactive idiotype. Antibodies elicited in the mouse in response to the hapten P-azophenylarsonate (Ars) have been particularly well studied in this regard and illustrate many of the problems involved in the structural characterization of idiotypes in general.
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单克隆抗胂酸抗体的结构分析：独特型特异性由重链决定。
影响因子：
3.6
作者：
Milner,EC;Capra,JD
通讯作者：
Capra,JD
单克隆 A/J 抗胂酸盐抗体中的基因重排。
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Estess,P;Otani,F;Milner,EC;Capra,JD;Tucker,PW
通讯作者：
Tucker,PW
源自交叉反应独特型方面不同的五种单克隆抗对偶氮苯胂酸抗体的轻链可变区的完整氨基酸序列。
DOI：
10.1073/pnas.78.12.7679
发表时间：
1981
影响因子：
11.1
作者：
Siegelman,M;Capra,JD
通讯作者：
Capra,JD
独特型阳性和独特型阴性 Ars 结合杂交瘤蛋白和 Ars 免疫血清的亲和力分析。
影响因子：
3.6
作者：
Rothstein,TL;Gefter,ML
通讯作者：
Gefter,ML
免疫球蛋白重链可变部分基因的体细胞突变。
DOI：
10.1126/science.6801765
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sims,J;Rabbitts,TH;Estess,P;Slaughter,C;Tucker,PW;Capra,JD
通讯作者：
Capra,JD