Human immunodeficiency virus type 1 tat directs transcription through attenuation sites within the mouse c-myc gene.
Human immunodeficiency virus type 1 tat directs transcription through attenuation sites within the mouse c-myc gene.
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人类免疫缺陷病毒 1 型 tat 通过小鼠 c-myc 基因内的减毒位点指导转录。
DOI：
10.1016/0022-2836(94)90031-0
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发表时间：
1994
影响因子：
5.6
通讯作者：
B. Peterlin
中科院分区：
文献类型：
--
作者：
S. Wright;X. Lu;B. Peterlin
The regulation of transcriptional elongation plays a central role in the expression of a number of cellular and viral genes. For example, levels ofc-myc RNA change during cellular proliferation and differentationviaalterations in transcriptional attenuation near the 5′ end of thec-myc gene. The protein that regulates transcription through attenuation sites inc-myc has not been identified. However, a candidate protein of equivalent function exists in the human immunodeficiency virus (HIV) genome, where the transactivator Tat increases transcriptional elongation through the HIV LTR and coding sequences by interacting with thetrans-acting-response (TAR) RNA stem-loop that is found at the 5′ end of all viral transcripts. By placing TAR 3′ to the P2 promoter of the mousec-myc gene, we demonstrate that Tat can also direct read-through transcription in mousec-myc in transfected HeLa cells. Thus we identified a viral transactivator whose cellular counterpart regulates transcriptional attenuation withinc-myc and other proto-oncogenes.
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影响因子：
10.5
作者：
SELBY, MJ;BAIN, ES;PETERLIN, BM
通讯作者：
PETERLIN, BM
转录和转录后机制对小鼠红白血病细胞 c-myc 表达调节的贡献。
影响因子：
10.5
作者：
Nepveu,A;Marcu,KB;Skoultchi,AI;Lachman,HM
通讯作者：
Lachman,HM
小鼠 c-myc 基因 P1 启动子转录过早终止。
DOI：
10.1073/pnas.88.24.11383
发表时间：
1991
影响因子：
11.1
作者：
Wright,S;Mirels,LF;Calayag,MC;Bishop,JM
通讯作者：
Bishop,JM
介导小鼠原癌基因 myc 转录减弱的 DNA 序列。
DOI：
10.1073/pnas.86.2.505
发表时间：
1989
影响因子：
11.1
作者：
Wright,S;Bishop,JM
通讯作者：
Bishop,JM
影响因子：
8
作者：
Spencer,CA;Groudine,M
通讯作者：
Groudine,M